Evidence map›Paper›PMID 41872411›Full record

ArticleAAPS PharmSciTech2026

Licofelone-Loaded Poly(d,l-Lactide-Co-Glycolide) Nanoparticles to Enhance Therapeutic Action: A Novel Approach for the Topical Management of Irritant Contact Dermatitis.

Khaled E Abuelella, Shaimaa Mosallam, Amira A El-Gazar, Ahmed Hassen Elshafeey, Sara M Soliman

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Khaled E AbuelellaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6th of October City, Giza, 12585, Egypt. Khaled_elsayed.pha@o6u.edu.eg.ORCID http://orcid.org/0000-0003-0149-6995
Shaimaa MosallamDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6th of October City, Giza, 12585, Egypt.ORCID http://orcid.org/0009-0001-3980-719X
Amira A El-GazarDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, October 6 University, 6th of October City, Giza, 12585, Egypt.ORCID http://orcid.org/0000-0002-8372-4682
Ahmed Hassen ElshafeeyDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.ORCID http://orcid.org/0000-0001-8934-4990
Sara M SolimanDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6th of October City, Giza, 12585, Egypt.ORCID http://orcid.org/0000-0003-3143-5894

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritant contact dermatitis (ICD) is a common and potentially debilitating chronic skin disorder that affects a large proportion of the worldwide population. In the present work, licofelone (LF) was incorporated into poly (d,l-lactide-co-glycolide) (PLGA) nanoparticles to design a topical nanocarrier systems intended to boost its therapeutic impacts in treatment of ICD. To achieve this objective, LF-loaded PLGA nanoparticles (PLGANPs) were fabricated utilizing the nanoprecipitation technique, and the formulation parameters were statistically optimized utilizing a D-optimal experimental design. Three independent variables were investigated: PLGA amount (X

Indexed as

Dermatitis, IrritantNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerAdministration, CutaneousAdministration, TopicalAnimalsDrug CarriersMaleMiceParticle SizePoloxamerRatsSkinDrug CarriersPoloxamerPolylactic Acid-Polyglycolic Acid Copolymerirritant contact dermatitislicofelonepoly(d,l-lactide-co-glycolide) nanoparticlestopical management

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.