Evidence map›Paper›PMID 41872382›Full record

ReviewJournal of bone and mineral metabolism2026

Stage-resolved geography of mouse skeletal stem cells.

Yiming Liam Liu, Xinyu Thomas Tang, Lin Veronica Chen, Bo O Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yiming Liam Liu *Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Xinyu Thomas Tang *Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Lin Veronica ChenENT Institute, Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai, China.
Bo O ZhouKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. bo.zhou@sibcb.ac.cn.

Funding

National Key Research and Development Program of China 2022YFA1104100
6 · The paper itself

Abstract

purposeFramed as the "geography" of skeletal stem cells (SSCs), this review aims to synthesize how developmental stages and local niche cues determine SSC identity and function. Ultimately, it seeks to provide a comprehensive conceptual basis for understanding skeletal development and regeneration.

resultBy moving beyond early in vitro concepts of colony-forming unit fibroblasts (CFU-Fs), recent advances in in vivo lineage tracing, clonal analyses, and spatial/single-cell omics have revealed pronounced heterogeneity within marrow SSCs and identified anatomically distinct populations in the cartilage, perichondrium, and periosteum (both fibrous and cambium layers). These specific compartments display a context-dependent division of labor: perichondrial and periosteal SSCs drive bone growth and fracture healing; cartilage-embedded progenitors maintain articular and growth-plate tissues; and marrow stromal SSCs primarily support steady-state bone remodeling and hematopoiesis, while responding variably after injury.

conclusionThe spatial and temporal geography of SSCs dictates their specialized roles across development, homeostasis, and repair. Mapping these anatomically distinct populations provides a crucial conceptual framework for understanding skeletal biology and developing targeted regenerative therapies.

Indexed as

Bone and BonesStem CellsAnimalsBone DevelopmentCell LineageMiceBone developmentBone regenerationCellular heterogeneitySkeletal stem cellsStem cell niche

Identifiers

PMID41872382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.