Evidence map›Paper›PMID 41872371›Full record

ArticleNature methods2026

Generating 3D models of complex carbohydrates with GLYCAM-Web.

Oliver C Grant, Daniel Wentworth, Samuel G Holmes, Rajan Kandel, David Sehnal, Xiaocong Wang, Yao Xiao, Preston Sheppard, Tobias Grelsson, Andrew Coulter and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  4. Loss of hemagglutination ability by H3N2 influenza A virus, subclade K.bioRxiv : the preprint server for biology · 2026
    Article
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  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Oliver C GrantComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0003-4835-5161
Daniel WentworthComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Samuel G HolmesComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Rajan KandelComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
David SehnalNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic.
Xiaocong WangComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Yao XiaoComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Preston SheppardComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Tobias GrelssonComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Andrew CoulterComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Grayson MillerComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Arunima SinghComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0001-5885-7478
Meenakshi NagarajanComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Bethany L FoleyComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0003-2786-7432
Robert J WoodsComplex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA. rwoods@ccrc.uga.edu.ORCID http://orcid.org/0000-0002-2400-6293

Funding

Selecting HA glycosylation for improved vaccine responsesR01AI155975 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WAN, XIUFENG HENRY, WOODS, ROBERT J · 2021 to 2025
$4.0M
Tools to enable non-specialists to model glycoconjugates and glycan-protein interactionsU01CA207824 · NCI · UNIVERSITY OF GEORGIA · PI FOLEY, B. LACHELE, WOODS, ROBERT J · 2016 to 2018
$1.7M
Transitioning GLYCAM-Web to a self-sustaining carbohydrate modeling serviceR24GM136984 · NIGMS · UNIVERSITY OF GEORGIA · PI WOODS, ROBERT J · 2020 to 2022
$1.4M
Continued Development and Maintenance of GLYCAM-WebR01GM100058 · NIGMS · UNIVERSITY OF GEORGIA · PI FOLEY, B. LACHELE, WOODS, ROBERT J · 2012 to 2015
$1.1M
National Science Foundation (NSF) DMR-1933525Natural Science Foundation of Hubei Province (Hubei Provincial Natural Science Foundation) 2025AFB695NCI NIH HHS U01 CA207824NIAID NIH HHS R01 AI155975NIGMS NIH HHS R01 GM100058NIGMS NIH HHS R24 GM136984
6 · The paper itself

Abstract

We present online three-dimensional (3D) structure-prediction tools at GLYCAM-Web ( www.glycam.org ) that can be used for generating experimentally consistent 3D structures of oligosaccharides for data interpretation, hypothesis generation, 3D visualization, molecular docking and further simulation. The tools support the modeling of an unlimited array of natural glycans and polysaccharides, glycosaminoglycans, engineered glycomaterials and glycoproteins. GLYCAM-Web is directly linked to external databases, such as the Protein Data Bank, facilitating comparison with experimental data.

Indexed as

CarbohydratesInternetModels, MolecularSoftwareCarbohydrate ConformationGlycoproteinsPolysaccharidesCarbohydratesGlycoproteinsPolysaccharides

Identifiers

PMID41872371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.