Evidence map›Paper›PMID 41872365›Full record

ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Management of bone health in cancer survivorship: a systematic review of clinical guidelines.

Victor Ki Chung Li, Stirling Cosgrove, Katelyn Collins, Paul Baden, Richard Blennerhassett, Bryan A Chan, Li-Heng Chan, Daphne Day, Belinda Goodwin, Alastair Kwok and 8 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Victor Ki Chung Li *Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Stirling Cosgrove *School of Public Health, University of Queensland, Brisbane, QLD, 4072, Australia.
Katelyn CollinsCancer Council Queensland, Fortitude Valley, QLD, Australia.
Paul BadenPrivate Lived Experience Consultant, Melbourne, Australia.
Richard BlennerhassettCentral Coast Haematology, Gosford, NSW, Australia.
Bryan A ChanSunshine Coast University Hospital, Birtinya, QLD, Australia.
Li-Heng ChanSchool of Psychology and Wellbeing, University of Southern Queensland, Springfield, QLD, Australia.
Daphne DayDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Belinda GoodwinCancer Council Queensland, Fortitude Valley, QLD, Australia.
Alastair KwokDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Debbie PackhamPrivate Lived Experience Consultant, Melbourne, Australia.
Kaung Tha KyawSchool of Psychology, Faculty of Health, Deakin University, 221 Burwood Highway, Burwood, VIC, Australia.
Christopher TodaroSchool of Psychology, Faculty of Health, Deakin University, 221 Burwood Highway, Burwood, VIC, Australia.
Kate WebberDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Janne WilliamsPrivate Lived Experience Consultant, Melbourne, Australia.
Ayse ZenginDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Lisa GrechDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia. l.grech@deakin.edu.au.
BHCS study team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAccelerated bone loss is a side effect of many anticancer treatments, posing significant health challenges for cancer survivors. The aim of this systematic review was to evaluate and synthesize recommendations for the management of bone health, specifically fracture and osteoporosis risk, in clinical guidelines for people with cancer.

methodsSearches related to bone health clinical guidelines for cancer patients were conducted in four electronic databases (PubMed, EMBASE, CINAHL, and Scopus). Data extraction was performed independently by multiple authors. Quality appraisal was performed using the Appraisal of Guidelines for Research & Evaluation II (AGREE II) instrument. Guidelines were categorized into three key focus areas (pharmacological interventions, screening, and lifestyle modifications) and compared across cancer types.

resultsA total of sixty-five guidelines were included in the systematic review. Two-thirds of guidelines included recommendations related to lifestyle (most commonly vitamin D and calcium supplementation), 76% related to screening (mostly bone mineral density via DXA), and 89% related to pharmacological intervention (most commonly bisphosphonates and denosumab). Fifty-four percent included recommendations in all three domains. Using the AGREE II tool, 42 guidelines were rated moderate and 23 high with strong scoring in domains of Scope and Purpose, Clarity of Presentation and Editorial Independence.

conclusionsFindings highlight variations in guideline quality, with many lacking holistic, multidisciplinary recommendations for bone health management. Further development of guidelines supporting patients impacted by multiple risk factors, and the inclusion of management strategies to mitigate compounding effects of cancer-related bone loss and age-related bone degradation among cancer patients, is recommended.

Indexed as

FractureOncologyOsteopeniaOsteoporosis

Identifiers

PMID41872365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.