Evidence map›Paper›PMID 41872243›Full record

ArticleScientific reports2026

Effect of pH on niacinamide skin permeation.

Thomas Sjöberg, Silvia Letasiova, Skaidre Jankovskaja, Nina Hrapovic, Christina Österlund, Emelie Nilsson, Johan Engblom, Peter Spégel, Sebastian Björklund

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas SjöbergDepartment of Biomedical Science, Malmö University, Malmö, Sweden.
Silvia LetasiovaMatTek In Vitro Life Science Laboratories, Bratislava, Slovakia.
Skaidre JankovskajaDepartment of Biomedical Science, Malmö University, Malmö, Sweden.
Nina HrapovicGlobal Research & Development, Oriflame Cosmetics AB, Stockholm, Sweden.
Christina ÖsterlundGlobal Research & Development, Oriflame Cosmetics AB, Stockholm, Sweden.
Emelie NilssonDepartment of Biomedical Science, Malmö University, Malmö, Sweden.
Johan EngblomDepartment of Biomedical Science, Malmö University, Malmö, Sweden.
Peter SpégelDepartment of Chemistry, Centre for Analysis and Synthesis, Lund University, Lund, Sweden.
Sebastian BjörklundDepartment of Biomedical Science, Malmö University, Malmö, Sweden. sebastian.bjorklund@mau.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niacinamide (NIA) is a widely used skincare ingredient with established benefits for skin barrier support, inflammation reduction, and dermal health. However, the mechanisms governing its transdermal delivery remain insufficiently understood, particularly regarding how formulation pH influences its permeation through the stratum corneum (SC). This study investigates how donor phase pH (5.0 vs. 7.4) modulates NIA skin permeation and how these effects relate to pH induced changes in SC electrical properties. Franz cell diffusion experiments were combined with electrical impedance spectroscopy (EIS) using full‑thickness human skin and 3D reconstructed epidermal tissue models. Permeation was quantified over 24 h and in pH switch experiments, while EIS characterized pH dependent changes in membrane resistance (R

Indexed as

NiacinamideSkinSkin AbsorptionAdministration, CutaneousDielectric SpectroscopyEpidermisHumansHydrogen-Ion ConcentrationNiacinPermeabilityNiacinNiacinamide3D reconstructed epidermisElectrical impedance spectroscopyNiacinamide conversionNicotinic acidSkin barrierTransdermal permeation pathways

Identifiers

PMID41872243
PMCPMC13018549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.