Evidence map›Paper›PMID 41872230›Full record

Articlenpj aging2026

Dietary metabolomic determinants of frailty through inflammation in the Canadian Longitudinal Study on Aging.

Talha Rafiq, Jinhui Ma, Divya Joshi, Alexandra Mayhew, Lauren Griffith, Edwin van den Heuvel, Parminder Raina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Talha RafiqDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Jinhui MaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Divya JoshiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Alexandra MayhewDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Lauren GriffithDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Edwin van den HeuvelDepartment of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands.
Parminder RainaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. praina@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty is a modifiable aging-related condition driven by chronic inflammation and metabolic dysregulation, which are influenced by diet. Metabolomic profiling captures individual metabolic responses and can uncover mechanisms linking diet to frailty. This study examined the effects of food-derived metabolites on changes in frailty risk, both directly and through inflammatory pathways. This longitudinal study included baseline and three-year follow-up data from 9992 participants aged 45-85 years from the Canadian Longitudinal Study on Aging with plasma metabolomic profiling. Inflammation was assessed using tumor necrosis factor alpha, interleukin-6, and C-reactive protein. Frailty was operationalized using Fried's frailty phenotype and the deficit accumulation model. Metabolomic clusters reflecting shared dietary sources and/or biological function were associated with frailty risk, mediated by inflammation. Plasmalogens and furan fatty acids from protein-based foods, and those with anti-inflammatory properties from fruits, vegetables, nuts and legumes, were associated with reduced frailty risk both directly and indirectly through lower inflammation. Conversely, higher omega-6 to omega-3 ratio from fish/eggs and trans-4-hydroxyproline from processed meat increased frailty risk through pro-inflammatory mechanisms. These findings emphasize inflammation as an important mechanism linking diet to frailty and highlight the importance of nutrient balance and interactions to inform nutrition strategies and promote healthy aging.

Identifiers

PMID41872230
PMCPMC13096115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.