ArticleNature communications2026
Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs.
Minkyu Lee, Xin Wang, Qihua Ye, George X Huang, Michael V Mandanas, Nils R Hallen, Laura Cho, Joshua A Boyce, Tanya M Laidlaw, Nora A Barrett
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Minkyu LeeJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8970-1895 Xin WangJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Qihua YeJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
George X HuangJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1711-4181 Michael V MandanasJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Nils R HallenJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Laura ChoJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Joshua A BoyceJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Tanya M LaidlawJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Nora A BarrettJeff and Penny Vinik Center for Translational Immunology Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA. nbarrett@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-2211-8811 Funding
Therapeutic Control of Aspirin-Exacerbated Respiratory DiseaseU19AI095219 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett · 2011 to 2026
$29.1MIMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2MType 2 Inflammation and Remodeling Elicited Through an LTE4/OXGR1-dependent pathwayR01AI134989 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett · 2019 to 2026
$5.1MLinking Mechanism to Outcome in Airway Inflammation and RemodelingK24HL179901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett · 2025 to 2026
$266kNHLBI NIH HHS K24 HL179901NIAID NIH HHS R01 AI134989NIAID NIH HHS T32 AI007306NIAID NIH HHS U19 AI095219U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K24HL179901U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI134989U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI007306U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI095219
6 · The paper itselfAbstract
Tissue-resident stem cells play an essential role in repairing barrier tissues subjected to frequent insults. However, the local cues that coordinate successful barrier repair or lead to tissue remodeling are largely unknown. Here we use murine models of airway injury, fate mapping, and null strains to identify a role for rare tuft epithelial cells in signaling to submucosal stem cells through the generation of cysteinyl leukotrienes (CysLTs) and activation of the CysLT receptor OXGR1. This results in mobilization of SOX9
Indexed as
Airway RemodelingSOX9 Transcription FactorStem CellsTuft CellsAnimalsFemaleHumansMiceMice, Inbred C57BLMice, KnockoutSox9 protein, mouseSOX9 Transcription Factor
Identifiers
PMID41872181
PMCPMC13172556
What OpenQuestion holds
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LicenceCC BY-NC-ND
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