Evidence map›Paper›PMID 41872173›Full record

ArticleTranslational psychiatry2026

Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort.

TianHong Zhang, JinYang Zhao, XiaoChen Tang, YanYan Wei, MingLiang Ju, Dan Zhang, YingYing Tang, HuiRu Cui, ZhengHui Yi, XiaoHua Liu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

TianHong Zhang *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China. zhang_tianhong@126.com.ORCID http://orcid.org/0000-0002-5379-7119
JinYang Zhao *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
XiaoChen Tang *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
YanYan Wei *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
MingLiang JuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
Dan ZhangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
YingYing TangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
HuiRu CuiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
ZhengHui YiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
XiaoHua LiuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.
HaiChun LiuDepartment of Automation, Shanghai Jiao Tong University, Shanghai, China.
ZiXuan WangShanghai Xinlianxin Psychological Counseling Center, Shanghai, China.
Tao ChenBig Data Research Lab, University of Waterloo, Waterloo, ON, Canada.
Jin GaoDepartment of Clinical Psychology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Qiang HuDepartment of Psychiatry, Wuhu Hospital of Anding Hospital (The Fourth People's Hospital of Wuhu), Wuhu, China.
LingYun ZengDepartment of Psychiatric Rehabilitation, Shenzhen Kangning Hospital, ShenZhen, GuangDong, China.
ChunBo LiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China.ORCID http://orcid.org/0009-0000-5029-069X
JiJun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Neuromodulation Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China. jijunwang27@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The T Helper (Th)1-Th2 imbalance has been observed during the transition from the clinical high-risk (CHR) state to psychosis. However, it remains unclear whether the complement system influences this imbalance during psychosis onset. This study aimed to investigate the dynamic interplay between complement activation and the Th1-Th2 balance during the progression of psychosis. A prospective case-control study was conducted to evaluate the Th1-Th2 balance, as indicated by interleukin(IL)-1Beta and IL-6 levels, in 49 individuals at CHR for psychosis and 26 age- and sex-matched healthy controls(HC). Based on the Th1-Th2 balance, the samples were divided into two groups: Th1 > Th2 and Th1 < Th2. Additionally, the levels of thirteen complement proteins (C1q, C2, C3, C3b, C4, C4b, C5, C5a, factor B, D, I, H, and Mannose-Binding Lectin) were measured at baseline. Correlations between cytokines and complement factors were examined, and longitudinal changes were assessed through a 1-year follow-up period. At baseline, significant differences were observed in complement characteristics (C4, C4b, C5, and B) between Th1 > Th2 and Th1 < Th2 balance states, highlighting variations in complement factors between the CHR and HC groups. In the CHR group, a negative association was noted between Th1-Th2 balance and complement factors, with significant correlations observed for components C4b, C5, I, C3, C4, and B. However, no significant correlation was found in the HC group. At follow-up, the Th1 < Th2 group exhibited a higher proportion of CHR individuals who converted to psychosis compared to the Th1 > Th2 group, indicating a significant association between Th1-Th2 balance and the onset of psychosis (χ

Indexed as

Complement System ProteinsPsychotic DisordersTh1 CellsTh1-Th2 BalanceTh2 CellsAdolescentAdultCase-Control StudiesComplement ActivationCytokinesDisease ProgressionFemaleHumansInterleukin-1betaLongitudinal StudiesMaleComplement System ProteinsCytokinesInterleukin-1beta

Identifiers

PMID41872173
PMCPMC13044246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.