Observational studyThe Laryngoscope2026
Evaluation of Systemic Inflammatory Markers in Predicting Malignancy in Parotid Gland Tumors.
Observational study in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate the diagnostic value of preoperative hematologic inflammatory indices in distinguishing benign from malignant parotid gland tumors and to assess their potential as adjunctive diagnostic tools.
methodsThis retrospective observational study included 259 patients who underwent parotidectomy at the Department of Otorhinolaryngology, Necmettin Erbakan University Faculty of Medicine, from January 2020 to January 2025. Demographic data, histopathologic diagnoses, and preoperative parameters were reviewed. Inflammatory indices (NLR, PLR, SII, SIRI, WMR, and NP/LHb) were calculated. Comparative analyses among pleomorphic adenoma, Warthin's tumor, and malignant tumors were performed using one-way ANOVA, Kruskal-Wallis, and post hoc tests. Receiver operating characteristic (ROC) analysis was used to determine discriminative performance.
resultsOf the 259 patients, 101 had pleomorphic adenoma, 107 had Warthin tumor, and 51 had malignant tumors. Warthin tumors demonstrated significantly higher white blood cell, neutrophil, lymphocyte, monocyte, and hemoglobin levels than both pleomorphic adenoma and malignant tumors (p < 0.001). Malignant tumors were associated with older age, larger tumor size and volume, higher NLR and PLR values, and lower lymphocyte, monocyte, and hemoglobin levels (all p < 0.05). ROC analysis identified age (cut-off: 60.5 years; AUC = 0.642) and tumor volume (cut-off: 24.75 cm
conclusionsPreoperative hematologic indices-NLR and PLR-may serve as inexpensive, accessible adjunctive tools in evaluating parotid masses. Integration of inflammatory indices into radiomics-based or nomogram-driven diagnostic models has the potential to improve diagnostic accuracy. LEVEL OF EVIDENCE: N/A.
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