ArticleZeitschrift fur medizinische Physik2026
DNA damage induction and repair in peripheral blood mononuclear cells induced by internal ex vivo irradiation with β- and γ-emitting radionuclides.
Article in Zeitschrift fur medizinische Physik, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- From photons and their detectors, ultra short and "longer" times to tiny and giant PETs, golden eyes, AI and surgical probes - Nuclear Medicine has it all.Zeitschrift fur medizinische Physik · 2026Article
- DNER drives glycolytic reprogramming in renal cell carcinoma by activating the JAK2/STAT3 signaling pathway.Frontiers in immunology · 2026Article
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7 authors.
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Abstract
purposeAim of the study was to investigate DNA damage induction and repair in peripheral blood mononuclear cells (PBMCs) after internal ex vivo irradiation with short-lived radionuclides with varying emission properties.
methodsBlood samples from healthy volunteers were irradiated with different activity concentrations for 1 h, resulting in absorbed doses to the blood from nominally 3 to 100 mGy. DNA double-strand breaks (DSBs) in PBMCs were assessed by quantifying radiation-induced γ-H2AX+53BP1-positive foci (RIF). In part A of the study, four different radionuclides (
resultsThe number of RIF increases linearly with the absorbed dose to the blood, independent of the radionuclide used for irradiation. The decline in RIF after irradiation can be described by an exponential function, with a trend towards higher repair rates at higher absorbed doses to the blood, i.e. (0.20±0.12) h⁻
conclusionOur results show a clear relationship between absorbed dose and DSB foci induced by internal irradiation in blood cells, independent of the emission properties of the particular radionuclide used. A better understanding of DNA damage repair dynamics after internal irradiation can improve future nuclear medicine therapies.
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