Evidence map›Paper›PMID 41871980›Full record

ArticleThe Journal of international medical research2026

Genetic background and management outcomes in primary bilateral macronodular adrenal hyperplasia: Implications for diagnosis and treatment-A retrospective cohort study.

Emine Özlem Gür, Serkan Karaıslı, Ümit Çavdar, Aslı Subaşıoğlu, Özlem Eren, Selda Gücek Hacıyanlı, Barış Önder Pamuk, Mehmet Sercan Ertürk, Mehmet Hacıyanlı

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Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Emine Özlem GürGeneral Surgery Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.ORCID 0000-0003-2749-2220
Serkan KaraıslıGeneral Surgery Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.
Ümit ÇavdarEndocrinology and Metabolism Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.ORCID 0000-0002-0411-553X
Aslı SubaşıoğluDepartment of Medical Genetics, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.
Özlem ErenEndocrinology and Metabolism Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.
Selda Gücek HacıyanlıGeneral Surgery Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.
Barış Önder PamukEndocrinology and Metabolism Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.
Mehmet Sercan ErtürkEndocrinology and Metabolism Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.
Mehmet HacıyanlıGeneral Surgery Clinic, Atatürk Training and Research Hospital, Katip Çelebi University Medical Faculty, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectivePrimary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing syndrome. Recent evidence, particularly the 2023 European Society of Endocrinology guidelines, clinically classifies cortisol excess into overt Cushing syndrome and mild autonomous cortisol secretion. Germline mutations in the Armadillo repeat-containing 5 (ARMC5) gene have been identified in 20%-55% of patients with PBMAH. This study aimed to describe the clinical, radiological, and biochemical characteristics of PBMAH; classify cortisol secretion according to updated guidelines; and evaluate surgical and conservative treatment outcomes.MethodsThis retrospective cohort study included 58 patients with bilateral adrenal macronodules who underwent

Indexed as

Armadillo Domain ProteinsCushing SyndromeAdrenalectomyAdrenal GlandsAdultAgedFemaleGenetic TestingGerm-Line MutationHumansHydrocortisoneMaleMiddle AgedRetrospective StudiesTreatment OutcomeArmadillo Domain ProteinsARMC5 protein, humanHydrocortisoneadrenal hyperplasiaArmadillo repeat-containing 5Cushing syndromegenetic screeningmild autonomous cortisol secretionPrimary bilateral macronodular adrenal hyperplasiaunilateral adrenalectomy

Identifiers

PMID41871980
PMCPMC13009886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.