Evidence map›Paper›PMID 41871959›Full record

ReviewVox sanguinis2026

Fundamentals of big data and artificial intelligence in transfusion medicine.

Amin T Turki, Christian Martin Brieske, Umut A Gurkan, Katja M Scheidler, O Berk Usta, Esa Turkulainen, Kamyar Arzideh, Christian Temme, René Hosch, Peter A Horn and 1 more

Abstract readReview
In one paragraph

Review in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amin T TurkiComputational Hematology Lab, Institute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany.ORCID https://orcid.org/0000-0003-1347-3360
Christian Martin BrieskeInstitute for Transfusion Medicine, University Hospital Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-8528-6022
Umut A GurkanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-0331-9960
Katja M ScheidlerComputational Hematology Lab, Institute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany.
O Berk UstaCenter for Engineering in Medicine & Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Esa TurkulainenResearch and Development, Finnish Red Cross Blood Service, Helsinki, Finland.
Kamyar ArzidehInstitute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany.
Christian TemmeInstitute for Transfusion Medicine, University Hospital Essen, Essen, Germany.
René HoschInstitute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany.
Peter A HornInstitute for Transfusion Medicine, University Hospital Essen, Essen, Germany.
Mikko ArvasResearch and Development, Finnish Red Cross Blood Service, Helsinki, Finland.ORCID https://orcid.org/0000-0002-6902-8488

Funding

Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
HLS-Affordable, quantitative microchip-electrophoresis for sickle cell disease screeningR44HL140739 · NHLBI · HEMEX HEALTH, INC. · PI GALEN, PETER · 2018 to 2025
$4.7M
Microfluidic Technology for Concurrent Assessment of Red Blood Cell Adhesion and Deformability (Administrative Supplement)R42HL162214 · NHLBI · BIOCHIP LABS, INC. · PI FEDERICI, CHIARA, GURKAN, UMUT A. · 2022 to 2024
$2.1M
Portable, affordable, quantitative microchip electrophoresis for hemoglobin A1C testingR42DK119048 · NIDDK · HEMEX HEALTH, INC. · PI GALEN, PETER · 2022 to 2023
$1.7M
Deep Supercooling of Red Blood Cells: Towards Practical Long Term StorageR01HL145031 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK, YARMUSH, MARTIN L · 2020 to 2023
$1.5M
A Modality-Agnostic Potency Assay Enabling Both Ex Vivo and In Vivo Genome Editing Therapeutics for Sickle Cell DiseaseU01AI176469 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI GIANNIKOPOULOS, PETROS, GURKAN, UMUT A. · 2023 to 2025
$1.4M
RHODA: Rapid Hemoglobin-Oxygen Dissociation AssayR41HL172662 · NHLBI · HEMEX HEALTH, INC. · PI GALEN, PETER, GURKAN, UMUT A. · 2024 to 2024
$296k
NCATS NIH HHS UM1 TR004528NHLBI NIH HHS R01 HL145031NHLBI NIH HHS R41 HL172662NHLBI NIH HHS R42 HL162214NHLBI NIH HHS R44 HL140739NIAID NIH HHS U01 AI176469NIDDK NIH HHS R42 DK119048
6 · The paper itself

Abstract

Within the digital transformation of medicine, transfusion medicine has quietly become a big-data discipline. The long-standing tradition of blood product standardization (e.g., ISBT-128) and large donor cohorts being followed over years-some of which are sampled in national biobank projects, build a favourable setting. In parallel, recent advances in artificial intelligence (AI) and data integration facilitate efficient data use for research and clinical care. Consequently, next-generation blood services might monitor donor phenotype data and match this information to AI-predicted recipient demands and their outcomes. Here, we attempt to provide a comprehensive introduction to the possibilities and challenges of big data and AI in transfusion medicine along with data integration opportunities related to the Fast Healthcare Interoperability Resources standard. We educate on the principles of AI and the digital transformation of transfusion medicine and analyse the evidence of blood establishments as digital platforms. We illustrate possible roadmaps for data integration and how federated learning initiatives and national networks may scale value while preserving donor and patient privacy. Finally, we exemplify the ongoing transformation with precision red blood cell (RBC) diagnostics using lab-on-a-chip and the digital crossmatch. The practice of transfusion medicine is undergoing transformation and experimentally appears to profit from synergies in precision diagnostics and AI. Its translation into routine practice remains a challenge for the current decade to leverage the full potential of blood establishments as 'big-data engines'.

Indexed as

Artificial IntelligenceBig DataBlood TransfusionTransfusion MedicineHumansAIbiobankcrossmatchdecision supportFHIRlab‐on‐a‐chip

Identifiers

PMID41871959
PMCPMC13066920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.