ReviewGenes & development2026
Nonhomologous end joining-the importance of end tethering and beyond.
Review in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Programmed Clonal Expansion Associated with V(D)J Recombination Drives an ATM-Dependent Vulnerability Underlying Preferential Lymphocyte Depletion and Myeloid Bias Following DNA Damage.bioRxiv : the preprint server for biology · 2026Article
- Ku70-SAP domain has an overlapping function with DNA-PKcs in limiting the lateral movement of the Ku ring along DNA.Nucleic acids research · 2026Article
- Lesions initiating spontaneous mitotic crossover are minimally subject to non-homologous end joining.bioRxiv : the preprint server for biology · 2026Article
- Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101.Nucleic acids research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The nonhomologous end joining (NHEJ) pathway is a major mechanism for repairing DNA double-strand breaks (DSBs), essential for lymphocyte development and for maintaining genome stability in postmitotic cells, including neurons. Under pathological conditions, NHEJ is also responsible for most oncogenic translocations and the repair of DSBs induced by chemotherapy/radiation. Advances in structural biology and single-molecule imaging have captured NHEJ at various stages of the reaction, revealing a modular, dynamic organization with built-in redundancy and resilience. Here, we describe NHEJ in five phases (end sensing, end protection, end tethering, end processing, and end ligation), highlighting their molecular features and transitions and how structural insights explain genetic interactions and physiological consequences, including lymphocyte development. Unlike other DSB repair mechanisms, NHEJ operates with minimal or no sequence complementarity, relying instead on protein assemblies to bridge and stabilize the two DNA ends. This review highlights the unique end-tethering phase, supported by at least five known overlapping machineries, all anchored on Ku.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.