Evidence map›Paper›PMID 41871906›Full record

ArticlePhytotherapy research : PTR2026

A Combined Colon Organoid-Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease.

Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phytotherapy research : PTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco MargiottaDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-4172-2478
Elena LucariniDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-3459-2660
Alessandra TotiDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-8435-6017
Maria Giovanna CataldiDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Clara CiampiDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0009-0005-3299-9263
Gina Rosalinda De NicolaResearch Centre for Vegetable and Ornamental Crops, Council for Agricultural Research and Economics (CREA), Pescia, Italy.ORCID https://orcid.org/0000-0002-2916-8662
Lorenzo Di Cesare MannelliDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0001-8374-4432
Carla GhelardiniDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0001-9856-8144

Funding

European Union - Next Generation EU CN00000041European Union - Next Generation EU ECS00000017Ministry of University and Research (MUR) 58514_DIPECC_23_27
6 · The paper itself

Abstract

Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity. Moringa oleifera constituents show beneficial properties that may counteract inflammation-induced epithelial dysfunction and visceral hypersensitivity. Among these, we investigated moringin (MOR), the isothiocyanate derived from the myrosinase (MYR)-mediated hydrolysis of glucomoringin (GMG). A three-stage experimental strategy was applied. First, murine colon organoids were exposed to a pro-inflammatory cytokine cocktail (CKs; TNF-α, IL-1β, IL-6; 10 ng mL

Indexed as

ColonInflammatory Bowel DiseasesIsothiocyanatesOrganoidsAnimalsColitisCytokinesDextran SulfateDisease Models, AnimalGanglia, SpinalIntestinal MucosaMaleMiceMice, Inbred C57BLMoringa oleiferaVisceral PainCytokinesDextran SulfateIsothiocyanatesmoringinepithelial‐neuronal signalingIBDMoringa oleiferaorganoidsvisceral pain

Identifiers

PMID41871906
PMCPMC13254238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.