Evidence map›Paper›PMID 41871765›Full record

ReviewAdvanced drug delivery reviews2026

Progress on cell therapy for skeletal muscle disorders.

Karim Azzag, Rita C R Perlingeiro

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Karim AzzagLillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Rita C R PerlingeiroLillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Greg Marzolf Jr. Muscular Dystrophy Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: perli032@umn.edu.

Funding

Preclinical studies of pluripotent stem cell-derived myogenic progenitors in non-human primatesR01AR078624 · NIAMS · UNIVERSITY OF MINNESOTA · PI GRAHAM, MELANIE LYNN, PERLINGEIRO, RITA C. R. · 2021 to 2025
$2.9M
Skeletal Muscle Regeneration from Pluripotent Stem CellsR01AR078571 · NIAMS · UNIVERSITY OF MINNESOTA · PI PERLINGEIRO, RITA C. R. · 2021 to 2025
$2.1M
Targeting Dystroglycanopathies using Pluripotent-derived Myogenic ProgenitorsR01AR081882 · NIAMS · UNIVERSITY OF MINNESOTA · PI Rita C. R. Perlingeiro · 2023 to 2026
$2.1M
NIAMS NIH HHS R01 AR078571NIAMS NIH HHS R01 AR078624NIAMS NIH HHS R01 AR081882
6 · The paper itself

Abstract

Cell therapy remains an attractive therapeutic option for the numerous genetic and non-genetic maladies affecting skeletal muscle. Since skeletal muscle is the largest tissue in the body, delivery has been notoriously challenging, but there have been significant advances, with several ongoing clinical trials of allogeneic and autologous cell transplantation aiming to replace diseased skeletal muscle with healthy and functional myofibers and muscle stem cells. Paracrine cellular approaches intended to enhance regeneration are also ongoing. In this review, we will provide an overview of the progress and current status of these different approaches, and discuss the forecast for future phases as well as the hurdles that need to be circumvented for the widespread application of cell therapy for skeletal muscle disorders.

Indexed as

Cell- and Tissue-Based TherapyMuscle, SkeletalMuscular DiseasesAnimalsHumansStem Cell TransplantationCell therapyClinical trialInduced pluripotent stem cellsMuscular dystrophyMyoblastsMyogenic progenitorsTransplantation

Identifiers

PMID41871765
PMCPMC13041513

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.