In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
23 authors.
Merijn B L Vriends *Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0001-9233-9412 Elisha Moran *Department of Chemistry, University of York Heslington, York YO10 5DD, United Kingdom.
Martín Calvelo *Departament de Química Inorgaǹica i Orgaǹica (Seccióde Química Orgaǹica) and Institut de Química TeorÌica I Computacional, Universitat de Barcelona, Barcelona 08028, Spain.
Thomas HansenDepartament de Química Inorgaǹica i Orgaǹica (Seccióde Química Orgaǹica) and Institut de Química TeorÌica I Computacional, Universitat de Barcelona, Barcelona 08028, Spain.ORCID 0000-0002-6291-1569 Isabelle B PicklesDepartment of Chemistry, University of York Heslington, York YO10 5DD, United Kingdom.ORCID 0000-0002-8495-5570 Xincheng XinDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0009-0005-9754-2686 Marieke BiezenoDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.
Zachary W B ArmstrongDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0002-4086-2946 Maria J FerrazDepartment of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0002-5765-9645 Lei LiDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0009-0009-2268-1971 Alice LilleyWorldwide Influenza Centre, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0002-8180-2798 Dmitri V FilippovDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0002-6978-7425 Qinghua LiaoDepartament de Química Inorgaǹica i Orgaǹica (Seccióde Química Orgaǹica) and Institut de Química TeorÌica I Computacional, Universitat de Barcelona, Barcelona 08028, Spain.ORCID 0000-0002-2260-8493 Sybrin P SchröderDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.
Gijsbert A van der MarelDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0001-9577-2123 Marta ArtolaDepartment of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0002-3051-3902 Johannes M F G AertsDepartment of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0001-8168-2565 Jeroen D C CodéeDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0003-3531-2138 Carme RoviraDepartament de Química Inorgaǹica i Orgaǹica (Seccióde Química Orgaǹica) and Institut de Química TeorÌica I Computacional, Universitat de Barcelona, Barcelona 08028, Spain.ORCID 0000-0003-1477-5010 Herman S OverkleeftDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The Netherlands.ORCID 0000-0001-6976-7005 Gideon J DaviesDepartment of Chemistry, University of York Heslington, York YO10 5DD, United Kingdom.ORCID 0000-0002-7343-776X Funding
EC | Horizon Europe | Excellent Science | HORIZON EUROPE European Research Council (ERC) ERC-2020-SyG-951231Royal Society (The Royal Society) Ken Murray Research Professorship
6 · The paper itselfAbstract
Influenza neuraminidase (NA) is a critical target for seasonal and pandemic antivirals, including the strains of current concern. Current treatments, such as Zanamivir and Oseltamivir, are limited by noncovalent binding and emerging resistance. We hypothesized that Oseltamivir aziridines would unite transition-state mimicry for tight binding, with aziridine-enabled covalent capture of the catalytic tyrosine, thereby supporting both therapy and activity-based quantification. Here, we present oseltamivir-based aziridines, inspired by cyclophellitol chemistry, that act as covalent inhibitors and activity-based probes via an
Indexed as
Antiviral AgentsAziridinesEnzyme InhibitorsNeuraminidaseOseltamivirViral ProteinsHumansInfluenza A Virus, H5N1 SubtypeAntiviral AgentsAziridinesEnzyme InhibitorsNeuraminidaseOseltamivirViral Proteinscarbohydrate-active enzymechemical biologycryoEMinfluenzaneuraminidase
Identifiers
PMID41871250
PMCPMC13038069
What OpenQuestion holds
Textmetadata
LicenceCC BY
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