Evidence map›Paper›PMID 41871244›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.

Taylor A DePauw, Kexin Gai, Jian Shen, Nicholas J Maurice, Ka Hyun Rhee, William J Valente, Christine H O'Connor, Weiguo Cui, Changwei Peng, Stephen C Jameson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taylor A DePauwCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
Kexin GaiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Jian ShenDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0001-8398-2318
Nicholas J MauriceCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.ORCID 0000-0002-2667-472X
Ka Hyun RheeCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
William J ValenteCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
Christine H O'ConnorUniversity of Minnesota Supercomputing Institute, Minneapolis, MN 55455.
Weiguo CuiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0003-1562-9218
Changwei PengCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
Stephen C JamesonCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.ORCID 0000-0001-9137-1146

Funding

Phenotypic, Functional and Transcriptional Heterogeneity in T Cell ExhaustionR01AI148403 · NIAID · VERSITI WISCONSIN, INC. · PI WEIGUO CUI · 2020 to 2026
$3.1M
Paving the way for bystander T cell immunotherapiesK99CA296729 · NCI · UNIVERSITY OF MINNESOTA · PI NICHOLAS JOSEPH MAURICE · 2025 to 2026
$228k
Role of S1PRs and KLF transcription factors in CD8T cell traffickingF31AI188630 · NIAID · UNIVERSITY OF MINNESOTA · PI Taylor A DePauw · 2025 to 2026
$73k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F31AI188630HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI148403HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI38903NCI NIH HHS K99 CA296729
6 · The paper itself

Abstract

Numerous transcriptional regulators have been associated with the differentiation pathways that lead to recirculating vs. tissue-resident memory T cells. However, it is unclear whether independent, coordinated expression of these regulators is required to determine residency vs. recirculation or whether there is a hierarchy, with some factors playing a dominant role in controlling T cell trafficking. We report that ablation of the gene encoding Kruppel-like factor 2 (KLF2) during CD8

Indexed as

CD8-Positive T-LymphocytesCell DifferentiationImmunologic MemoryKruppel-Like Transcription FactorsMemory T CellsAnimalsLymphocyte ActivationMiceMice, KnockoutKlf2 protein, mouseKlf3 protein, mouseKruppel-Like Transcription FactorsKLF2memory CD8 T cellstissue-resident

Identifiers

PMID41871244
PMCPMC13037849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.