Evidence map›Paper›PMID 41871225›Full record

ArticleRespiration; international review of thoracic diseases2026

Feasibility and Safety of a Robotic-Assisted Optical Navigation System for Pulmonary Nodule Percutaneous Cryoablation: A Prospective, Single-Center, Single-Arm Pilot Study.

Xiuping Wu, Weiyi Wan, Lianyue Yang, Xu Shi, Jielong Lin, Weizhan Luo, Xinni Wang, Guodong Lu, Yanwei Chen, Shiyue Li

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Article in Respiration; international review of thoracic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xiuping WuDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Weiyi WanDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lianyue YangDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xu ShiDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jielong LinDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Weizhan LuoDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xinni WangDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guodong LuDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yanwei ChenDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, chenyw@gzhmu.edu.cn.
Shiyue LiDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, lishiyue@gird.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Percutaneous cryoablation under imaging guidance is an effective therapeutic modality for pulmonary nodules, but the conventional technique relies on surgical complexity and physician experience. Computed tomography (CT)-guided robotic-assisted percutaneous puncture technique provides three-dimensional reconstruction, optimal needle trajectory planning, and monitoring of real-time respiratory motion, thereby enabling safe ablation of lung nodules. This study aimed to clinically evaluate the feasibility and safety of a robotic-assisted optical navigation system when utilized for CT-guided percutaneous cryoablation of pulmonary nodules.

methodsPatients who underwent CT-guided percutaneous cryoablation via a robotic-assisted optical navigation system were prospectively enrolled in our study. The primary outcomes were the technical success rate and the technical efficacy rate, and the preoperative, intraoperative, and postoperative variables were recorded and analyzed for each patient.

resultsA total of 37 consecutive patients with a single nodule were ultimately enrolled in the present study. The technical success rate was 100%, and the technical efficacy rate of robotic-assisted cryoablation was 100% with no recurrence during the 1-month follow-up. The average number of needle adjustments per nodule was 0.82 ± 1.19 in this study, with a mean deviation of 3.47 ± 2.47 mm. The mean numbers of CT acquisitions and dose length product used during needle insertion were 3.44 ± 1.65 and 638.86 ± 434.44 mGy cm, respectively. The duration of needle placement was 15.95 ± 5.06 min, whereas the total procedural duration was 99.32 ± 32.00 min. Notably, the deviation was found to be significantly correlated with the lobar location and was more prominent in the lower lobe. However, no significant correlations were observed with the nodule type, size, distance to the pleura, chest wall thickness, needle trajectory length, decubitus position, or the pulmonary function status of the patient. Moreover, no significant changes were found in the pulmonary function of the patients before or after the treatment. No major grade ≥3 complications were observed. However, among the minor complications, there were 5 cases (13.51%) of immediate pneumothorax, 2 cases (5.41%) of delayed pneumothorax, and 1 case (2.70%) of hemorrhage.

conclusionThe feasibility, safety, and preliminary effectiveness of robotic-assisted optical navigation system for CT-guided percutaneous cryoablation of pulmonary nodules were demonstrated; however, long-term efficacy and safety require further validation through multicenter, large-scale, prospective clinical studies with extended follow-up. </p>.

Indexed as

CryosurgeryLung NeoplasmsRobotic Surgical ProceduresSolitary Pulmonary NoduleAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsProspective StudiesSurgery, Computer-AssistedTomography, X-Ray ComputedTreatment OutcomeNavigation systemPercutaneous cryoablationPulmonary noduleRobotic-assisted

Identifiers

PMID41871225
PMCPMC13008396

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