ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2026
Elevated Intra-Abdominal Pressure as a Prognostic Marker of Enteral Nutrition Intolerance and Adverse Outcomes in Neurocritical Care: A Retrospective Cohort Study.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
<p>Objective: This study investigated the association between intra-abdominal pressure (IAP), enteral nutrition tolerance, and the clinical outcomes.
methodsIn this retrospective cohort study, 120 patients admitted to a neurological critical care unit between 2021 and 2024 were evaluated. Only the patients receiving enteral nutrition for five or more days were included. IAP was measured every 6 h via bladder catheterization. Data regarding gastrointestinal complications, nutritional adequacy (volume ratio), and hospital outcomes were analyzed using multivariate logistic regression and random-effects modeling.
resultsElevated IAP (exceeding 14 mm Hg) was present in 92% of the cohort. Patients with gastrointestinal complications 54 (45%) exhibited significantly higher IAP (16.1 vs. 15.45 mm Hg; p = 0.0212), significantly longer stays in the neurocritical care unit (p = 0.0002) and longer total hospitalizations (p = 0.0002) compared to those without complications 66 (55%). Diarrhea (33%) and constipation (31%) were the most frequent complications. Multivariate analysis identified IAP as an independent predictor of prolonged intensive care stay (RR = 2.209), extended total hospitalization (RR = 2.203), and mortality (RR = 2.062). Furthermore, high IAP was significantly associated with a failure to achieve ninety percent of nutritional goals (p < 0.0001).
conclusionIAP is a reliable indicator of enteral nutrition intolerance and systemic deterioration in neurocritical care. Routine monitoring of abdominal pressure should be integrated into clinical practice to enhance risk stratification and optimize nutritional delivery in patients with acute neurological injury. </p>.
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