Evidence map›Paper›PMID 41871180›Full record

ArticleCirculation2026

Epicardial Complement C3 Activation in Neonatal Cardiac Regeneration.

Anthony Y Zhu, Maggie S Chen, Annika M T Braun, Laura Ben Driss, Elizabeth K Griffin, Undine-Sophie Deumer, Angie Delgado, Niranjana Natarajan, Khanh Ha, Yuriy Milobog and 3 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anthony Y ZhuDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).ORCID 0009-0002-0228-0838
Maggie S ChenDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).
Annika M T BraunDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).
Laura Ben DrissDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).
Elizabeth K GriffinDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).
Undine-Sophie DeumerDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).ORCID 0000-0002-1148-4675
Angie DelgadoDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).
Niranjana NatarajanDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).ORCID 0000-0003-4967-3524
Khanh HaDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY (K.H., Y.M., M.H., J.R.M.).ORCID 0000-0001-8115-3639
Yuriy MilobogDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY (K.H., Y.M., M.H., J.R.M.).
Maddelyn HoehnDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY (K.H., Y.M., M.H., J.R.M.).
Jason R McCarthyDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY (K.H., Y.M., M.H., J.R.M.).ORCID 0000-0002-5302-2030
Richard T LeeDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA (A.Y.Z., M.S.C., A.M.T.B., L.B.D., E.K.G., U.-S.D., A.D., N.N., R.T.L.).ORCID 0000-0003-4687-1381

Funding

Complement Activation and Initiation of Heart RegenerationR01HL137710 · NHLBI · HARVARD UNIVERSITY · PI LEE, RICHARD T · 2018 to 2021
$1.7M
Investigating the Role of Macrophages in Heart Failure with Preserved Ejection FractionR00HL157689 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Niranjana Natarajan · 2024 to 2026
$747k
NHLBI NIH HHS R00 HL157689NHLBI NIH HHS R01 HL137710
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

angiogenesiscardiovascular systemcomplement activationcomplement C3macrophage activationpericardiumregeneration

Identifiers

PMID41871180
PMCPMC13012260

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.