ArticleFEBS open bio2026
The cooperative regulation of miR-221 by APE1 and AUF1 impacts p27
Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is a multifunctional protein involved in DNA repair, transcriptional regulation, and redox signaling, which significantly contributes to cancer progression and chemoresistance. Recent studies revealed a new role in RNA metabolism, specifically influencing the processing of some onco-microRNAs (miRs). The interaction of APE1 with AU-rich element RNA-binding protein 1 (AUF1) is crucial in regulating RNA stability under oxidative stress conditions. Our research shows that APE1 and AUF1 bind pre-miR-221, preferentially once oxidized, thus affecting miR-221 maturation and impacting gene transcription, such as the cyclin-dependent kinase inhibitor p27
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