Evidence map›Paper›PMID 41870857›Full record

ReviewProbiotics and antimicrobial proteins2026

Lactic Acid Bacteria with Probiotic Potential Regulating Macrophages: Mechanisms, Regulatory Features, and Clinical Applications.

Zibo Mai, Bosen Wang, Qijun Hu, Zheng Jia, Jiaqing Wang, Boyu Liu, Junwei Ge

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zibo MaiHeilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Bosen WangHeilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Qijun HuHeilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Zheng JiaHeilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Jiaqing WangHeilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Boyu LiuHeilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Junwei GeHeilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. gejunwei@neau.edu.cn.

Funding

National Natural Science Foundation of China 31672532
6 · The paper itself

Abstract

The significance of the intestinal microbiota in overall health has gained increasing recognition. Probiotic supplementation promotes intestinal microbial homeostasis. As a key component of probiotics, lactic acid bacteria (LAB) are widely utilized in the prevention and management of various diseases owing to their well-established safety profile and remarkable immunomodulatory properties. Their regulatory effect on myeloid cells, particularly macrophages, is critically important. This article systematically reviews the substantial impacts of LAB on macrophages, including effects on macrophage quantity, polarization, autophagy, apoptosis, metabolism, trained immunity, and so on, which contribute to the control of disease progression. The regulation of macrophages by LAB exhibits characteristics such as strain-specificity, dose dependence, and correlation with administration routes, and may mediate systemic effects via the gut-X axis. Furthermore, LAB have demonstrated therapeutic potential in treating macrophage-associated diseases, such as obesity and impaired wound healing. Finally, this review discusses development suggestions for the combined application of LAB and future development directions in this field, including screening and combined application of strains, exploring and utilizing the mechanism of transgenerational effect, aiming to enhance the application of LAB in antibiotic therapy and the development of human and animal health industries.

Indexed as

LactobacillalesMacrophagesProbioticsAnimalsGastrointestinal MicrobiomeHumansTrained ImmunityLactic acid bacteriaMacrophageMechanismRegulationStrain-specificityTrained immunity

Identifiers

PMID41870857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.