Evidence map›Paper›PMID 41870756›Full record

ReviewBiotechnology letters2026

Advancing the frontier of plant-based therapeutics: critical innovations in molecular farming and bioprocess Integration.

Kalidas Gowtham, Balamurugan Shanmugaraj, Lohith Saran Thangavel, Aksittha Srinivasan, Ashwini Malla

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biotechnology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kalidas GowthamDepartment of Biotechnology, PSG College of Arts & Science, Coimbatore, Tamil Nadu, 641014, India.
Balamurugan ShanmugarajDepartment of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.
Lohith Saran ThangavelDepartment of Biotechnology, PSG College of Arts & Science, Coimbatore, Tamil Nadu, 641014, India.
Aksittha SrinivasanDepartment of Biotechnology, PSG College of Arts & Science, Coimbatore, Tamil Nadu, 641014, India.
Ashwini MallaDepartment of Biotechnology, PSG College of Arts & Science, Coimbatore, Tamil Nadu, 641014, India. ashwini@psgcas.ac.in.ORCID http://orcid.org/0000-0003-3490-0704

Funding

PSG PSGCAS/IRSG/2024-2025/Biotechnology/004
6 · The paper itself

Abstract

Plant molecular farming (PMF) has emerged as a promising strategy for producing biopharmaceuticals and high-value biomolecules in plant systems. In this review, we present a comprehensive synthesis of current methodologies while introducing novel approaches to genetic transformation, protein expression, glycan engineering, and downstream processing. We offer in-depth analyses of recent advancements such as CRISPR/Cas9-mediated pathway editing, synthetic biology frameworks for optimizing protein yield and quality, and integrated bioprocessing solutions that enhance purification efficiency. Further, detailed case studies are discussed to illustrate actionable strategies, and future research directions are proposed to bridge current gaps. By focusing on transformative techniques and critical problem-solving perspectives, this review aims to guide researchers toward more effective and scalable PMF applications.

Indexed as

Biological ProductsMolecular FarmingPlantsPlants, Genetically ModifiedBiotechnologyCRISPR-Cas SystemsPolysaccharidesSynthetic BiologyBiological ProductsPolysaccharidesBiopharmaceutical productionDownstream processingGlycan engineeringPlant molecular farmingSynthetic biologyTransgenic expression

Identifiers

PMID41870756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.