Evidence map›Paper›PMID 41870755›Full record

ArticleJournal of gastrointestinal cancer2026

Clusters of Anthropometric Features in Colorectal Cancer Patients with Synchronous Metastases and Their Association with Overall Survival and RAS Mutation.

Vincenzo Formica, Cristina Morelli, Michela Rofei, Maria Alessandra Calegari, Silvia Riondino, Gemma Del Pace, Andrea Divizia, Tonia Cenci, Giovanni Trovato, Augusto Orlandi and 5 more

Registry-linked trialAbstract readClinical Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03873064 (Body Mass Index), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03873064 recruitingnot on this map

Body Mass Index (BMI) and Quality of Life (QoL) in Cancer Patients

TypeobservationalSponsorUniversity of Rome Tor VergataRan2019 to 2034Enrolled1,380ConditionsNeoplasm Malignant, Body Weight, Quality of Life
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vincenzo FormicaMedical Oncology Unit, Department of Systems Medicine, 'Tor Vergata' University, Rome, Italy. vincenzo.formica@uniroma2.it.
Cristina MorelliMedical Oncology Unit, Department of Systems Medicine, 'Tor Vergata' University, Rome, Italy.
Michela RofeiMedical Oncology Unit, Department of Systems Medicine, 'Tor Vergata' University, Rome, Italy.
Maria Alessandra CalegariOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, 00168, Italy.
Silvia RiondinoMedical Oncology Unit, Department of Systems Medicine, 'Tor Vergata' University, Rome, Italy.
Gemma Del PaceMedical Oncology Unit, Department of Systems Medicine, 'Tor Vergata' University, Rome, Italy.
Andrea DiviziaDepartment of Surgery, University Rome of "Tor Vergata", Rome, Italy.
Tonia CenciAnatomic Pathology, Department of Integrated Care Processes, University of Rome "Tor Vergata", Viale Oxford 81, Rome, 00133, Italy.
Giovanni TrovatoOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, 00168, Italy.
Augusto OrlandiAnatomic Pathology, Department of Integrated Care Processes, University of Rome "Tor Vergata", Viale Oxford 81, Rome, 00133, Italy.
Giovanna Del Vecchio BlancoGastroenterology Unit, Policlinico Universitario Tor Vergata, Rome, Italy.
Rolando Maria D'AngelilloRadiation Oncology, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Giuseppe SicaDepartment of Surgery, University Rome of "Tor Vergata", Rome, Italy.
Giovanni MonteleoneGastroenterology Unit, Policlinico Universitario Tor Vergata, Rome, Italy.
Mario RoselliMedical Oncology Unit, Department of Systems Medicine, 'Tor Vergata' University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnthropometric traits—such as height, body mass index (BMI), and age—are shaped by genetic, nutritional, and environmental factors, which may also be influential in colorectal cancer (CRC). We investigated whether sex-adjusted variations in these parameters could be associated with different subtypes of CRC and overall survival outcomes.

methodsWe analyzed patients with synchronous metastatic CRC enrolled in the prospective BMI-QoL study (NCT03873064). Age, height, and BMI were standardized and subjected to k-means clustering (k = 2, 25 random initializations). Principal component analysis was used to visualize cluster separation in two dimensions. “Core cluster members” were defined using sex-specific cutoffs for all three variables, excluding borderline cases. Difference in Overall survival (OS) between clusters was assessed using Kaplan–Meier and Cox proportional hazards models; clinical and molecular features were compared using chi-square and Mann–Whitney tests.

resultsTwo reproducible clusters emerged. Cluster 1 comprised younger, taller, normal-to-overweight patients; Cluster 2 included older, shorter, underweight patients. Core cluster 1 members (n = 23) had significantly longer OS than core cluster 2 members (n = 31) (median OS 51.1 vs. 22.0 months; HR 2.28, p = 0.03), with survival curves diverging beyond 24 months. Non-core members had intermediate OS (median 31 months). Age, height, and BMI individually were not significant OS predictors. RAS wild-type tumors were more prevalent in core cluster 1 (61%) than core cluster 2 (32%, p = 0.03). CEA levels and metastatic patterns did not differ between clusters.

conclusionSex-adjusted anthropometric profiling identifies two prognostically distinct mCRC subtypes. The association of better survival with higher BMI, younger age and taller stature—alongside increased prevalence of RAS wild-type tumors—supports the biological relevance of these profiles. Larger prospective validation integrating anthropometric and genomic data is warranted.

Indexed as

Colorectal NeoplasmsNeoplasms, Multiple Primaryras ProteinsAgedAnthropometryBody Mass IndexCluster AnalysisFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMutationPrognosisProspective Studiesras Proteinsanthropometric indicesclustering analysismetastatic colorectal cancer

Identifiers

PMID41870755

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.