Evidence map›Paper›PMID 41870662›Full record

ArticleAIDS and behavior2026

Structural and Social Drivers of Pre-Exposure Prophylaxis (PrEP) Literacy Disparities Among Men who have Sex with Men in China: A PrEP Care Cascade Analysis.

Mojun Ni, Hao Lin, Phoenix Kit-Han Mo, Chun Chang, Jinghua Li, Wangnan Cao

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Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mojun NiDepartment of Social Medicine and Health Education, School of Public Health, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.
Hao LinDepartment of Social Medicine and Health Education, School of Public Health, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.
Phoenix Kit-Han MoSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Chun ChangDepartment of Social Medicine and Health Education, School of Public Health, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.
Jinghua LiFaculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macao SAR, 999078, China.
Wangnan CaoDepartment of Social Medicine and Health Education, School of Public Health, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China. wangnancao@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-6163-2760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the proven efficacy of pre-exposure prophylaxis (PrEP) for HIV prevention, uptake among men who have sex with men (MSM) in China remains low. Guided by the PrEP care cascade framework, we conceptualized PrEP literacy as a social practice shaped by structural and community dynamics, encompassing four dimensions: essential knowledge, eligibility self-assessment, access to medication, and adherence to follow-up care. We examine how social support, community norms, and structural barriers intersect to shape PrEP literacy disparities. A cross-sectional study was conducted in partnership with 20 community-based organizations (CBOs) across 20 Chinese cities (December 2023). We surveyed 1,400 MSM with an electronic questionnaire assessing demographics, sexual behaviors, PrEP-related norms, social support, and PrEP literacy using a validated 14-item scale aligned with the cascade framework. Multivariable logistic regression models were used to identify factors associated with PrEP literacy, adjusting for sociodemographic confounders. Participants exhibited stark disparities across PrEP literacy dimensions. Eligibility assessment proficiency was the lowest, with widespread misperceptions about clinical indications. Social-structural factors significantly predicted PrEP literacy: MSM reporting stronger PrEP-supportive norms (adjusted odds ratio [AOR] = 1.05, p < 0.001) and social support (AOR = 1.03, p < 0.001) had higher odds of adequate literacy. PrEP literacy gaps among Chinese MSM reflect structural inequities in health education and community-level misperceptions about eligibility. Interventions must address social-structural barriers through norm-driven, community-led strategies -peer navigation programs to reframe eligibility awareness and partnerships with CBOs to decentralize PrEP access. Policymakers should integrate PrEP literacy into national HIV prevention frameworks by leveraging China's existing CBO infrastructure.

Indexed as

Anti-HIV AgentsHealth Knowledge, Attitudes, PracticeHealth LiteracyHIV InfectionsHomosexuality, MalePre-Exposure ProphylaxisAdultChinaCross-Sectional StudiesHumansMaleMiddle AgedSocial SupportSurveys and QuestionnairesYoung AdultAnti-HIV AgentsCommunity normsHealth literacyHIV preventionMen who have sex with men (MSM)PrEP care cascadeSocial determinants of health

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.