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ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

Frontotemporal-orbitozygomatic approach for pediatric cranio-orbital tumors: a single-center experience.

Yafei Wang, Yufan Chen, Jia Wei, Li Chen, Wei Wei, Lei Li, Mawei Jiang, Tianlang Hu, Cheng Wang, Yunkun Wang and 1 more

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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11 authors.

Yafei Wang *Department of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Yufan Chen *Department of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Jia Wei *Department of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Li ChenOphthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Wei WeiDepartment of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Lei LiDepartment of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Mawei JiangDepartment of Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Tianlang HuDepartment of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Cheng WangDepartment of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Yunkun WangDepartment of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. wangyunkun@xinhuamed.com.cn.
Chenran ZhangDepartment of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. zhangchenran@xinhuamed.com.cn.

Funding

the National Natural Science Foundation of China 82170798
6 · The paper itself

Abstract

objectiveTo evaluate the surgical anatomy, technical nuances, and early postoperative outcomes of the frontotemporal-orbitozygomatic (FTOZ) approach in a consecutive series of pediatric cranio-orbital communicating tumors. To evaluate the surgical anatomy, technical nuances, and early postoperative outcomes of the frontotemporal-orbitozygomatic (FTOZ) approach in a consecutive series of pediatric cranio-orbital communicating tumors. Unilateral Dodge Class I Optic Pathway Glioma without Neurofibromatosis Type 1 (OPG-uDCI) was selected as an index pathology to illustrate the specific application of this approach in a representative subgroup.

methodsThirteen children (five female, eight male) with imaging and histopathology confirmed cranio-orbital communicating tumours were managed at a single institution from April 2020 to August 2024.

resultsAt operation, the median age was 24 months (interquartile range 4-156 months). Postoperative surveillance extended for a median of 21 months (interquartile range 9-62 months). Notably, 10 patients had a follow-up period of at least 12 months. Histopathological diagnoses included: OPG, rhabdomyosarcoma, mature teratoma, optic nerve sheath meningioma, langerhans cell histiocytosis, and ewing-like sarcoma. Surgical complications included one case of severe postoperative chemosis with corneal ulceration requiring enucleation and one wound infection. There were no operative mortalities in this series. During follow-up, no patients with OPG demonstrated contralateral visual field changes postoperatively. Among the seven participants in whom macroscopic total excision was accomplished, neoplastic relapse subsequently developed in three.

conclusionsThe FTOZ approach is a technically feasible corridor for resection of pediatric cranio-orbital tumors in selected cases. However, given the small sample size, short follow-up, and occurrence of major complications, these findings should be considered preliminary. Definitive conclusions regarding safety and efficacy await larger comparative studies.

Indexed as

Neurosurgical ProceduresOrbitOrbital NeoplasmsSkull NeoplasmsAdolescentChildChild, PreschoolFemaleFrontal BoneHumansInfantMaleOptic Nerve GliomaRetrospective StudiesTemporal BoneTreatment OutcomeMature teratomaOptic pathway gliomaRhabdomyosarcoma

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