Evidence map›Paper›PMID 41870300›Full record

ArticleBehavioural neurology2026

Anxiolytic and Antidepressant-Like Effects of a Probiotic Mixture HMLH123 Potentially via the Serotonergic Pathway in Wistar Rats.

Gilberto Uriel Rosas-Sánchez, León Jesús Germán-Ponciano, Angélica Yanet Nápoles-Medina, Blanca Rosa Aguilar-Uscanga, Mario Eduardo Flores-Soto, Cesar Soria-Fregozo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gilberto Uriel Rosas-SánchezPrograma de Estancias Posdoctorales por Mexico, SECIHTI, Centro Universitario de Los Lagos, Universidad de Guadalajara, Lagos de Moreno, Jalisco, Mexico, udg.mx.ORCID https://orcid.org/0000-0002-0753-0069
León Jesús Germán-PoncianoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico, uv.mx.ORCID https://orcid.org/0000-0001-9185-2900
Angélica Yanet Nápoles-MedinaLaboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO) Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico.ORCID https://orcid.org/0009-0005-2583-6255
Blanca Rosa Aguilar-UscangaDepartamento de Farmacobiología, Laboratorio de Microbiología Industrial, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, udg.mx.ORCID https://orcid.org/0000-0002-8100-2598
Mario Eduardo Flores-SotoLaboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO) Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico.ORCID https://orcid.org/0000-0002-5194-8569
Cesar Soria-FregozoDepartamento de Ciencias de la Tierra y de la Vida, Centro Universitario de Los Lagos, Universidad de Guadalajara, Lagos de Moreno, Jalisco, Mexico, udg.mx.ORCID https://orcid.org/0000-0002-7829-6222

Funding

Secretaría de Ciencia, Humanidades, Tecnología e Innovación 1099710Secretaría de Ciencia, Humanidades, Tecnología e Innovación 714866
6 · The paper itself

Abstract

Anxiety and depression are a major health problem worldwide with increasing prevalence and limitations in pharmacologic treatment. The gut-brain axis has emerged as a potential therapeutic target, with probiotics showing promise in the regulation of mental health. To evaluate the anxiolytic and antidepressant-like effects of a probiotic mixture HMLH123 and its pharmacologic interaction with fluoxetine, 60 male Wistar rats were divided into six experimental groups that received either vehicle, fluoxetine (0.5 or 1 mg/kg), probiotic mixture HMLH123 200 μL to a concentration of 10

Indexed as

Anti-Anxiety AgentsAntidepressive AgentsProbioticsAnimalsAnxietyBehavior, AnimalDepressionDisease Models, AnimalFluoxetineMaleRatsRats, WistarSerotoninAnti-Anxiety AgentsAntidepressive AgentsFluoxetineSerotoninantidepressantanxiolyticelevated plus mazeforced swim testLactiplantibacillus sp.microbiota–gut–brain axisopen field test

Identifiers

PMID41870300
PMCPMC13580832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.