Evidence map›Paper›PMID 41870126›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Directed Evolution of an Efficient Polycarbonate Depolymerase With Exceptional Operational Stability.

Henry A Jones, Amy E Hutton, Dominic Harris-Jukes, John Davidson, Linus O Johannissen, Colin W Levy, Michael P Shaver, Anthony P Green

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Henry A JonesManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.
Amy E HuttonManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.
Dominic Harris-JukesSustainable Materials Innovation Hub, Department of Materials, University of Manchester, Manchester, UK.
John DavidsonManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.
Linus O JohannissenManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.
Colin W LevyManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.
Michael P ShaverSustainable Materials Innovation Hub, Department of Materials, University of Manchester, Manchester, UK.
Anthony P GreenManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.ORCID 0000-0003-0454-1798

Funding

Engineering and Physical Sciences Research Council EP/023755/1Engineering Biology Network for Specialty Chemicals UKRI APP66024Future Biomanufacturing Hub EP/S01778X/1Henry Royce Institute for Advanced Materials EP/P025021/1Henry Royce Institute for Advanced Materials EP/P025498/1Henry Royce Institute for Advanced Materials EP/R00661X/1Henry Royce Institute for Advanced Materials EP/S019367/1Polestar and the European Regional Development Fund OC15R19PRoyal Academy of Engineering RCSRF2324-17-43
6 · The paper itself

Abstract

We recently developed a high-throughput directed evolution platform for engineering polymer degrading enzymes, and showcased its utility through the development of an efficient and thermostable variant of IsPETase, termed HotPETase. Here, we show that this platform can be used to re-engineer PET degrading enzymes for the recycling of other aromatic-containing commodity polymers. Promiscuous poly(bisphenol-A carbonate) (PC) depolymerase activity of LCC

Indexed as

Directed Molecular EvolutionHydrolasesPolycarboxylate CementBenzhydryl CompoundsBisphenol A CompoundsEnzyme StabilityPhenolsPolycarbonatesTemperatureBenzhydryl Compoundsbisphenol ABisphenol A CompoundsHydrolasesPhenolspolycarbonatePolycarbonatesPolycarboxylate Cementbiocatalysisdepolymerizationdirected evolutionpolycarbonatepolymer hydrolase

Identifiers

PMID41870126
PMCPMC13110763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.