Evidence map›Paper›PMID 41870094›Full record

ArticleAntimicrobial agents and chemotherapy2026

Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC

Miquel Sánchez-Osuna, Paula Bierge, Inmaculada Gómez-Sánchez, Judith Guitart-Matas, Víctor Monsálvez, Patricia Rabanal, Ana P Pereira, Ana R Freitas, Luisa Peixe, Mateu Espasa and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Miquel Sánchez-Osuna *Laboratori de Recerca en Microbiologia i Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.ORCID 0000-0001-5267-4814
Paula Bierge *Laboratori de Recerca en Microbiologia i Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Inmaculada Gómez-SánchezLaboratori de Recerca en Microbiologia i Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Judith Guitart-MatasLaboratori de Recerca en Microbiologia i Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Víctor MonsálvezServei de Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Patricia RabanalLaboratori de Recerca en Microbiologia i Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Ana P PereiraUnidade de Ciências Biomoleculares Aplicadas (UCIBIO), Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Ana R FreitasUnidade de Ciências Biomoleculares Aplicadas (UCIBIO), Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.ORCID 0000-0002-7326-4133
Luisa PeixeUnidade de Ciências Biomoleculares Aplicadas (UCIBIO), Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Mateu EspasaServei de Microbiologia, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Oriol GaschServei de Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.
Carla NovaisUnidade de Ciências Biomoleculares Aplicadas (UCIBIO), Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Oscar Q PichLaboratori de Recerca en Microbiologia i Malalties Infeccioses, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.ORCID 0000-0003-3561-630X

Funding

Instituto de Salud Carlos III PI24/01294
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsCephalosporin ResistanceCephalosporinsEnterococcus faeciumPoint MutationAmpicillinBacterial ProteinsCefotaximeCeftarolineCeftriaxoneGene Expression Regulation, BacterialHumansMicrobial Sensitivity TestsPolymorphism, Single NucleotideThird Generation CephalosporinsWhole Genome SequencingAmpicillinAnti-Bacterial AgentsBacterial ProteinsCefotaximeCeftarolineCeftriaxoneCephalosporinsThird Generation Cephalosporinsampicillin-susceptible Enterococcus faeciumcephalosporin intrinsic resistanceCroSNusGPBP5RpoB

Identifiers

PMID41870094
PMCPMC13148053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.