Evidence map›Paper›PMID 41870091›Full record

ArticleApplied and environmental microbiology2026

Tunable low-rate genomic recombination with Cre-

Elisa Garabello, Hyun Yoon, Matthew C Reid, Andrea Giometto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Elisa GarabelloSchool of Civil and Environmental Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0003-4772-1078
Hyun YoonSchool of Civil and Environmental Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0003-0652-6057
Matthew C ReidSchool of Civil and Environmental Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-5185-7678
Andrea GiomettoSchool of Civil and Environmental Engineering, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-0544-6023

Funding

Evolutionary dynamics of dense, spatially structured, and antagonistic microbial populationsR35GM147493 · NIGMS · CORNELL UNIVERSITY · PI Andrea Giometto · 2022 to 2026
$2.0M
Human Frontier Science Program RGEC28/2023National Science Foundation 1905175NIGMS NIH HHS R35 GM147493NIH HHS 1R35GM147493
6 · The paper itself

Abstract

The ability to induce heritable genomic changes in response to environmental cues is valuable for environmental biosensing, for experimentally probing microbial ecology and evolution, and for synthetic biology applications. Site-specific recombinases provide a route to genetic memory via targeted DNA modifications, but their high specificity and efficiency are offset by leaky expression and limited tunability in prokaryotes. We developed a tightly regulated, titratable Cre recombinase system for

Indexed as

ArsenitesBiosensing TechniquesEscherichia coliIntegrasesRecombination, GeneticSynthetic BiologyarseniteArsenitesCre recombinaseIntegrasesarsenicbioavailabilitybiosensorgenetic memorygenetic switchrecombinase

Identifiers

PMID41870091
PMCPMC13101479

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.