ArticleAntimicrobial agents and chemotherapy2026
A phase I study to evaluate the effect of hepatic impairment on the pharmacokinetics and safety of suraxavir marboxil: a novel oral antiviral for influenza.
Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Suraxavir marboxil (GP681, abbreviated as suraxavir) is a novel, orally active small-molecule polymerase acidic (PA) inhibitor for the treatment of influenza. Its active metabolite, GP1707D07, specifically inhibits PA endonuclease activity. Suraxavir has been approved for use in adolescents (≥12 years) and adults with uncomplicated influenza A and B. This non-randomized, open-label, parallel-group phase I clinical trial evaluated the effects of hepatic impairment on the pharmacokinetics (PK) and safety of suraxavir. Subjects with mild or moderate hepatic impairment and matched healthy controls (
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