Evidence map›Paper›PMID 41870045›Full record

ArticlemBio2026

Evasion of humoral immune responses by a key mutational region of the S2 subunit in PEDV variants.

Shiyu Liu, Gege Zhang, Jingyuan Xie, Boshui Yuan, Weilu Guo, Yunchuan Li, Rongli Guo, Min Sun, Mi Hu, Yongxiang Zhao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shiyu LiuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Gege ZhangKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Jingyuan XieKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Boshui YuanKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Weilu GuoTaizhou Polytechnic College, Taizhou, China.
Yunchuan LiKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Rongli GuoKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Min SunKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Mi HuKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Yongxiang ZhaoKey Laboratory of Veterinary Biological Engineering and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Fei LiuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.ORCID 0000-0003-2811-9479
Qi PengInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang, China.ORCID 0000-0002-8128-1697
Bin LiCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.ORCID 0000-0003-1318-7081
Baochao FanCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.ORCID 0000-0001-9780-5080

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 2010, millions of piglets have died from porcine epidemic diarrhea virus (PEDV) variant strains. Compared with classical strains, variants exhibit enhanced virulence and immune evasion capacity, rendering classical strain-based vaccines poorly effective. However, the critical mutants responsible for increased pathogenicity and immune evasion remain unclear. This study aims to identify the key mutations that drive humoral immune evasion in PEDV variants and to elucidate further the underlying molecular mechanisms. Cross-neutralization assays and recombinant virus screening identified the 894-993 amino acid (aa) mutation region of the S2 subunit as a key determinant of humoral immune evasion in variants. The challenge experiments in piglets demonstrated that the 894-993 aa mutation region plays a critical role in determining variants' virulence. Subsequent vaccination-challenge experiments further clarified the pivotal contribution of the 894-993 aa mutation region in the humoral immune evasion

Indexed as

Coronavirus InfectionsImmune EvasionImmunity, HumoralPorcine epidemic diarrhea virusSpike Glycoprotein, CoronavirusAnimalsAntibodies, NeutralizingAntibodies, ViralMutationSwineSwine DiseasesVirulenceAntibodies, NeutralizingAntibodies, ViralSpike Glycoprotein, Coronavirusimmune evasionmembrane fusionpathogenicityPEDVS protein

Identifiers

PMID41870045
PMCPMC13059768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.