Evidence map›Paper›PMID 41869562›Full record

ArticleiScience2026

Loss of Ezh2 promotes M2-like macrophage polarization in hepatocellular carcinoma.

Kittin Weerasopon, Atsadang Boonmee, Patipark Kueanjinda, Benjawan Wongprom, Thitiporn Pattarakankul, Thadaphong Sukdee, Tanapat Palaga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kittin WeerasoponGraduate Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Atsadang BoonmeeDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Patipark KueanjindaDepartment of Pathology, UMass Chan Medical School, University of Massachusetts, Worcester, MA 01655, USA.
Benjawan WongpromCenter of Excellence in Immunology and Immune-Mediated Diseases, Chulalongkorn University, Bangkok 10330, Thailand.
Thitiporn PattarakankulDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Thadaphong SukdeeCenter of Excellence in Immunology and Immune-Mediated Diseases, Chulalongkorn University, Bangkok 10330, Thailand.
Tanapat PalagaCenter of Excellence in Immunology and Immune-Mediated Diseases, Chulalongkorn University, Bangkok 10330, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) promote tumor progression and metastasis. Ezh2, the catalytic component of Polycomb repressive complex 2, mediates transcriptional silencing through H3K27me3 deposition. Here, we demonstrate that Ezh2 deficiency in bone marrow-derived macrophages (BMDMs) enhances M2-like polarization upon exposure to conditioned media from Hepa1-6 hepatocellular carcinoma cells. RNA-seq analysis revealed stronger induction of M2-associated genes in conditioned

Indexed as

cancerepigeneticsimmunology

Identifiers

PMID41869562
PMCPMC12999353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.