Evidence map›Paper›PMID 41869556›Full record

ArticleCase reports in ophthalmology

Retinal Vasculopathy in Inflammatory Cerebral Amyloid Angiopathy: A Case Report of Peripheral Marker of Treatment Response.

Ludovica Gargiulo, Francesco Cutrupi, Francisco Esoin, Lisa Melzi, Benedetta Storti, Nicola Rifino, Anna Bersano, Stefania Bianchi Marzoli

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ludovica GargiuloNeuro-Ophthalmology Center and Electrophysiology Laboratory, Department of Ophthalmology, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Francesco CutrupiDepartment of Ophtalmology,Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Francisco EsoinFacultad de Medicina, Neurologia, Universidad National Mar Del Plata, Buenos Aires, Argentina.
Lisa MelziNeuro-Ophthalmology Center and Electrophysiology Laboratory, Department of Ophthalmology, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Benedetta StortiDepartment of Neurology, IRCC Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.
Nicola RifinoDepartment of Neurology, IRCC Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.
Anna BersanoDepartment of Neurology, IRCC Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.
Stefania Bianchi MarzoliNeuro-Ophthalmology Center and Electrophysiology Laboratory, Department of Ophthalmology, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Inflammatory cerebral amyloid angiopathy (CAA-ri) is a rare immune response to vascular amyloid-β. Ocular involvement is exceptional, and the retina may represent an accessible biomarker of disease activity. Case Presentation: A 67-year-old woman with probable CAA-ri developed recurrent floaters and transient visual obscurations during steroid tapering, with bilateral optic disc edema and peripapillary hemorrhages. Multimodal retinal imaging supported an inflammatory hemorrhagic retinal arteriolar microangiopathy (normal CSF opening pressure; TREX1 negative). Retinal findings resolved after intensified immunosuppression (steroids plus mycophenolate), recurred during tapering, and resolved again after switching to cyclophosphamide with steroid escalation; brain MRI remained largely unchanged and brain biopsy later confirmed inflammatory CAA. Conclusion: Multimodal retinal imaging may provide a dynamic, sensitive peripheral biomarker to monitor disease activity and treatment response in CAA-ri, even when cerebral MRI appears stable.

Indexed as

AmyloidosisCase reportHemorrhageInflammatory cerebral amyloid angiopathyOptic disc edemaRetinaRetinal angiopathy

Identifiers

PMID41869556
PMCPMC13002238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.