ArticleJournal of drug and alcohol research2020
Alcohol Modulation of Amyloid Precursor Protein in Alzheimer's Disease.
Article in Journal of drug and alcohol research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Integrated Network and Transcriptomic Analyses Identify a Candidate Ethanol-ADAM17 Molecular Axis Associated with Glioblastoma Progression.International journal of molecular sciences · 2026Article
- Gender dependent modulation of opioid dependance genes and signaling pathways in HIV-1 Transgenic rats at morphine tolerance.Journal of neurovirology · 2025Article
- Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson's Disease.International journal of molecular sciences · 2023Article
- Using IPA tools to characterize molecular pathways underlying the involvement of IRF7 in antiviral response to HIV.NeuroImmune pharmacology and therapeutics · 2022Article
- The COVID-19 Pandemic: Reflections of Science, Person, and Challenge in Academic Research Settings.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Heavy alcohol use increases the risk of Alzheimer's Disease (AD); however, the underlying mechanisms are not addressed. The key chemical of alcohol beverages is ethanol (EtOH), and acetaldehyde is its key toxic metabolite. QIAGEN Ingenuity Pathway Analysis (IPA) bioinformatics tool was used to investigate and compare the holistic impact of EtOH and acetaldehyde on AD. An extensively researched biomarker of AD pathologies is amyloid-beta of which the precursor is amyloid precursor protein (APP). Molecules associated with APP or EtOH were collected from the QIAGEN Knowledge Base, and 313 molecules were overlapping between the molecule sets. Using the "Pathway Explorer" tool, 40 of the 313 molecules were found to change due to EtOH exposure and influence APP and were compared with acetaldehyde-mediated molecule expression changes. A pathway analysis of the findings related to these 40 molecules showed that EtOH increases APP expression at a confidence of
Indexed as
Identifiers
41869499PMC13004628What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.