Evidence map›Paper›PMID 41869443›Full record

ArticleJournal of Cancer2026

FAM188B promotes progression of hepatocellular carcinoma by regulating YAP/TAZ via interaction with USP10.

Siwei Hu, Yuting Wen, Yihong Chen, Yuliang Fang, Mingshan Mu, Linglan Tu, Wenhu Chen, Kangsheng Tu, Xin Liu, Qiuran Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Siwei HuSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Yuting WenSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Yihong ChenSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Yuliang FangSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Mingshan MuSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Linglan TuSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Wenhu ChenSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Kangsheng TuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shanxi, China.
Xin LiuZhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College Hangzhou, 310014, Zhejiang, China.
Qiuran XuSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
Dongsheng HuangZhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College Hangzhou, 310014, Zhejiang, China.
Xiaoyan LiSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and its incidence and mortality rates remain high. Therefore, new diagnostic and therapeutic approaches are urgently required. Family with sequence similarity 188 member B (FAM188B) encodes an evolutionarily conserved protein that is highly expressed in various cancers. While FAM188B has been implicated in the progression of several tumors, its role in HCC progression remains unknown. Methods: We analyzed FAM188B expression in HCC using The Cancer Genome Atlas (TCGA) and The University of Alabama at Birmingham Cancer data analysis Portal (UALCAN) databases. Functional studies included Results: FAM188B was found highly expressed in HCC cells and associated with poor prognosis. Both Conclusion: Our findings reveal that FAM188B plays a crucial role in enhancing HCC cell proliferation, migration, and invasion, primarily through regulating the USP10/YAP/TAZ signaling axis, which was validated

Indexed as

FAM188Bhepatocellular carcinomaUSP10YAP/TAZ pathway

Identifiers

PMID41869443
PMCPMC13003555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.