ReviewClinical, cosmetic and investigational dermatology2026
Peripheral Nerve Ultrasound Findings in Leprosy: A Scoping Review of Echogenicity, Cross-Sectional Area, and Vascularization Across 15 Studies.
Review in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Leprosy is a chronic granulomatous disease caused by Objective: This review aimed to map and synthesize diagnostic role of peripheral nerve ultrasound, focusing on echogenicity, cross-sectional area, and vascularization, in detecting leprosy-related neuropathy. Methods: This scoping review was conducted in accordance with the PRISMA-ScR guidelines and included 15 studies assessing echogenicity, CSA, and vascularity in leprosy patients (sample sizes ranging from 20-308 participants). Results: Ultrasound consistently identified nerve abnormalities across 15 studies, including hypoechogenicity and fascicular pattern loss (up to 72% of nerves), CSA enlargement, and Doppler vascularity (11-45%) correlating with active inflammation. Reported CSA cut-offs (10-50 mm Conclusion: This scoping review demonstrates ultrasound's utility for early leprosy-related neuropathy detection. Ultrasound shows superior sensitivity over clinical palpation for subclinical involvement, particularly valuable for household contacts and pure neural leprosy. However, methodological heterogeneity precludes definitive diagnostic thresholds. Future research should standardize protocols and validate ultrasound parameters to optimize clinical application and disability prevention in endemic regions.
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