ArticleInternational journal of nanomedicine2026
pH-Sensitive Long-Circulating Nanoliposomes with CU1 for Effective Against Lung Cancer.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- cRGD-Targeted Nanoparticles Co-Loaded with Ag, Quercetin and PD-L1 siRNA with Combined Antibacterial and Immunotherapeutic Functions AgainstInternational journal of nanomedicine · 2026Article
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Authors and funding
11 authors.
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Abstract
Introduction: To address the poor water solubility and low bioavailability of the curcumin derivative CU1, this study constructed a long-circulating pH-sensitive nanoliposome (CU1-LCpHL) as its delivery system. Methods: The physicochemical properties, stability, and anti-lung cancer efficacy of CU1-LCpHL were systematically evaluated, including in vitro cellular assays (cellular uptake, apoptosis, proliferation, and migration), in vivo pharmacokinetics and pharmacodynamics, mechanistic studies, and immunohistochemical analysis. Results: CU1-LCpHL presented a spherical morphology with uniform particle size. Its lyophilized powder remained stable for at least three months at 25°C and exhibited sustained-release characteristics. In vitro experiments demonstrated that, compared to free curcumin (CU), free CU1, and long-circulating stable nanoliposomes (CU1-LSLN), CU1-LCpHL promoted more efficient cellular uptake, induced apoptosis, and significantly inhibited the proliferation and migration of lung cancer cells. Pharmacokinetic studies revealed that the area under the curve (AUC Conclusion: CU1-LCpHL significantly enhances the delivery efficiency and antitumor efficacy of CU1, representing a promising nano-drug delivery system for lung cancer therapy.
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