Evidence map›Paper›PMID 41869354›Full record

ArticleFrontiers in immunology2026

Silencing of circRERE(4-5) inhibits ONECUT2-mediated tumorigenesis and metastasis in gastric cancer.

Hua Xiao, Bowen Yu, Min Ma, Chonglei Zhong, Ming Shi, Yongxin Ye, Qionggui Hu, Shiyi Liu, Qinpeng Long, Kaiyu Zhu and 1 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hua Xiao *Department of Hepatobiliary and Intestinal Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
Bowen Yu *Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Min MaDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Chonglei ZhongDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ming ShiDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yongxin YeDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Qionggui HuDepartment of Radiotherapy, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Shiyi LiuDepartment of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qinpeng LongDepartment of Pediatrics, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Kaiyu ZhuCenter for Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Fei LongDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The leading cause of mortality for gastric cancer (GC) patients is metastasis. Investigating the mechanisms that drive the dissemination of GC could reveal crucial aspects of tumour biology and potentially lead to valuable therapeutic strategies. Circular RNAs (circRNAs), which are extensively expressed in tumours, are involved in a range of biological processes, such as cancer metastasis and cancer immunity. In the present study, the role of circRNAs in the progression and dissemination of GC was investigated. Methods: CircRNAs expression were analyzed using GEO datasets and qRT-PCR. The role of circRNAs in the progression of GC was investigated using functional assays, molecular experiments, and in vivo xenograft models. Results: We identified a circRNA, circRERE(4-5) (circBase ID: hsa_circ_0009594), which facilitated GC progression. CircRERE(4-5) was notably elevated in GC tissues and cells, and plasma circRERE(4-5) levels correlated closely with GC size and metastasis. Knockdown of circRERE(4-5) suppressed the growth and movement of GC cells through a pathway involving miR-571 and one cut homeobox 2 (ONECUT2). Moreover, antisense oligonucleotides targeting circRERE(4-5) suppressed the growth and spread of xenograft tumours in mice. Conclusion: Our research uncovers the functional and diagnostic significance of circRERE(4-5) and highlights circRNAs as pivotal factors in GC development and spread.

Indexed as

CarcinogenesisHomeodomain ProteinsRNA, CircularStomach NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticGene SilencingHumansMaleMiceMice, NudeMicroRNAsHomeodomain ProteinsMicroRNAsRNA, CircularcircRERE(4-5)circular RNAgastric cancermetastasisONECUT2

Identifiers

PMID41869354
PMCPMC13002853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.