ReviewFrontiers in immunology2026
Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Deconstructing Risk: A Machine Learning-Guided Logistic Regression Model for Predicting Early Mucosal Edema Following Prophylactic Ileostomy in Elderly Rectal Cancer Patients.International journal of general medicine · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ileostomy is extensively utilized as a preventive method to avert anastomotic leakage and other severe complications in colorectal surgery, serving as a valuable model for both study and clinical applications. The ileostoma, as a window, allows for the observation of a range of pathophysiological changes of complications in the mucosal layer of the defunctioned ileum, as well as in the defunctioned colon. It is precisely the changes in the intestinal microecology caused by ileostomy that may affect the efficacy of anti-tumor immunotherapy. Various interventions exist to flush the defunctioned intestine via the window, aiming to mitigate both short-term and long-term complications. These interventions include the use of normal saline, short-chain fatty acids, autologous intestinal fluid, and probiotics. Furthermore, there is a growing perspective advocating for the early closure (EC) of the ileostomy as a potentially superior management strategy. Moving forward, continued exploration of the window promises to yield further benefits for patients.
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Registered trials
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