Evidence map›Paper›PMID 41869345›Full record

ArticleFrontiers in immunology2026

The transcription factor ZNF683 marks an exhaustion-like GZMB

Mingtong Hou, Zhao Mi, Shiyu Ouyang, Wenbo Wang, Guiquan Zhao, Shengbao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingtong HouThe Second Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.
Zhao MiThe Second Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.
Shiyu OuyangThe Second Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.
Wenbo WangEmergency Center, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu, China.
Guiquan ZhaoEmergency Center, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu, China.
Shengbao WangEmergency Center, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection and remains a major global cause of mortality. Persistent immunosuppression contributes to secondary infections and adverse outcomes, yet the mechanisms underlying late-phase T-cell dysfunction remain incompletely understood. Methods: We integrated publicly available human peripheral blood mononuclear cell single-cell RNA sequencing with a clinically relevant cecal ligation and puncture (CLP) mouse model to characterize CD8 Results: Single-cell analysis identified a GZMB Conclusion: ZNF683 is associated with an exhaustion-like GZMB

Indexed as

CD8-Positive T-LymphocytesDNA-Binding ProteinsSepsisAnimalsAntigens, CDDisease Models, AnimalHumansLymphocyte Activation Gene 3 ProteinMaleMiceT-Cell ExhaustionAntigens, CDDNA-Binding ProteinsLymphocyte Activation Gene 3 ProteinGZMBimmunosuppressionlag3sepsisT cell exhaustionZNF683

Identifiers

PMID41869345
PMCPMC13002821

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.