Evidence map›Paper›PMID 41869281›Full record

ArticleCell biomaterials2026

Mechanical characterization of

Hanwen Fan, Ellen Busschers, Hutomo Tanoto, Anoushka Prabhu, Dinh Sang Bui, Preston Nguyen, Julia Kehl, Carla Berrospe-Rodriguez, Yuqing Chen, Carolina Leynes and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hanwen FanJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Ellen BusschersDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Hutomo TanotoJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Anoushka PrabhuDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Dinh Sang BuiJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Preston NguyenDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Julia KehlJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Carla Berrospe-RodriguezJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Yuqing ChenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Carolina LeynesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Guillermo AguilarJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Yangjin BaeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Brendan LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Yuxiao ZhouJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.

Funding

Project 3: 3D ImagingU54AR068069 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI VERNON R SUTTON · 2014 to 2026
$19.3M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Targeting TGFb In Osteogenesis ImperfectaR01AR081904 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI Yangjin Bae, Brendan Lee · 2023 to 2026
$2.4M
NIAMS NIH HHS R01 AR081904NIAMS NIH HHS U54 AR068069NICHD NIH HHS P50 HD103555
6 · The paper itself

Abstract

This study presents a novel integrated multiscale approach that combines whole-bone strain mapping, nanoscale mechanical testing, and compositional profiling to reveal how structural changes across scales impair bone quality in osteogenesis imperfecta (OI). OI is a genetic disorder caused by mutations in type I collagen that leads to fragile bones. Using femurs from male

Indexed as

AFM–infrared spectroscopy (AFM-IR)atomic force microscopy (AFM)bone biomechanicsdigital volume correlation (DVC)osteogenesis imperfecta (OI)Raman spectroscopy

Identifiers

PMID41869281
PMCPMC13004629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.