Evidence map›Paper›PMID 41869274›Full record

ArticleImmunotherapy advances2026

Neuraminidase A controls pneumococcal recognition and fate: deficiency enhances immune sensing and intracellular survival, while treatment promotes phagocytic clearance.

Kristine Farmen, Georgia Yfanti, Fabienne Geers, Johanna Hollenbeck, Miguel Tofiño Vian, Thomas P Kohler, Sven Hammerschmidt, Federico Iovino

Abstract read
In one paragraph

Article in Immunotherapy advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristine FarmenDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden.
Georgia YfantiDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden.
Fabienne GeersDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden.
Johanna HollenbeckDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden.
Miguel Tofiño VianDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden.
Thomas P KohlerDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Sven HammerschmidtDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Federico IovinoDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden.ORCID https://orcid.org/0000-0001-5249-9120

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

intracellular survivalmacrophagesmeningitismicroglianeuraminidase AphagocytosisStreptococcus pneumoniae

Identifiers

PMID41869274
PMCPMC13001807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.