ArticleCureus2026
Pertussis-SARS-CoV-2 Co-infection in Infants at Mohammed VI University Hospital, Marrakech, Morocco.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundViral-bacterial co-infections may worsen the clinical course of COVID-19; however, the clinical characteristics of pertussis co-infection with SARS-CoV-2 in infants remain poorly described.
methodsWe conducted a retrospective study (from January 2024 to September 2025) at Mohammed VI University Hospital in Marrakech. Infants younger than 24 months with clinical suspicion of pertussis underwent multiplex respiratory polymerase chain reaction (PCR) testing using the FilmArray Respiratory Panel 2.1 plus panel (BioMérieux, Marcy-l'Étoile, France). Co-infection was defined as the simultaneous detection of
resultsAmong 628 tested patients (including 419 children), 69 were diagnosed with pertussis. Nine infants (mean age: 0.08 years) had pertussis-SARS-CoV-2 co-infection. Typical pertussis features were present in all patients. Common findings included respiratory distress (6/9), oxygen desaturation requiring supplemental oxygen (4/9), wheezing (4/9), elevated C-reactive protein (CRP) (5/9), leukocytosis (9/9), lymphocytosis (7/9), including one case of marked lymphocytosis, and thrombocytosis (8/9), with platelet counts ≥ 600 G/L in three cases. Chest imaging revealed interstitial patterns (1/9), focal infiltrate (1/9), or hyperinflation (2/9). The median length of hospital stay was four days.
conclusionPertussis-SARS-CoV-2 co-infection in early infancy is uncommon but clinically relevant. Syndromic PCR enabled prompt diagnosis, early initiation of macrolide therapy, and rapid implementation of isolation to limit transmission. Larger studies are needed to better define severity determinants and identify gaps in vaccine-preventable disease coverage.
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