Doxycycline-Induced Phototoxicity Localized to Vitiligo-Affected and Sun-Exposed Skin.

Sydney Dong, Claudine Harris, Alexandra Ly, Pamela S Lee

Abstract readCase Reports

In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sydney DongDepartment of Internal Medicine, Harbor University of California Los Angeles Medical Center, Torrance, USA.

Claudine HarrisDepartment of Infectious Diseases, Harbor University of California Los Angeles Medical Center, Torrance, USA.

Alexandra LyDepartment of Internal Medicine, Harbor University of California Los Angeles Medical Center, Torrance, USA.

Pamela S LeeDepartment of Infectious Diseases, Harbor University of California Los Angeles Medical Center, Torrance, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitiligo is a chronic autoimmune disorder characterized by depigmented skin secondary to melanocyte loss, which may increase susceptibility to phototoxic drug reactions. We describe a case of doxycycline-induced phototoxicity selectively affecting vitiliginous and sun-exposed skin, with complete resolution after drug discontinuation. This case highlights melanin's protective role against ultraviolet-mediated injury and demonstrates that patients with pigmentary disorders may be at higher risk for localized phototoxic reactions from photosensitizing medications. Clinicians should maintain vigilance, emphasize photoprotection, and consider alternative therapies with a lower risk of phototoxicity in such populations.

Indexed as

doxycyclinedrug toxicitymelaninrashvitiligo

Identifiers

PMID41869147

DOI10.7759/cureus.103789

PMCPMC13002259

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.