ArticleCureus2026
Oxidative and Nitrosative Stress Biomarkers in Personnel of Radiodiagnostic Laboratory Services Exposed to Ionizing Radiation.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Association of G Protein-Coupled Estrogen Receptor (GPER) Polymorphisms with Ionizing Radiation Exposure in Healthcare Workers.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIonizing radiation (IR) is widely used in medical imaging and interventional procedures. However, chronic occupational exposure may result in oxidative and nitrosative stress, contributing to long-term health risks.
objectiveThis study aimed to evaluate oxidative and nitrosative stress biomarkers in radiodiagnostic laboratory personnel occupationally exposed to IR compared to non-exposed healthy controls.
methodsA cross-sectional study was conducted, including 100 radiodiagnostic laboratory personnel (exposed group) and 100 age- and sex-matched healthy controls. Venous blood samples were analyzed for catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), and 3-nitrotyrosine (3-NTx). Standard spectrophotometric and enzyme-linked immunosorbent assay (ELISA) methods were used. Group comparisons were performed using Student's t-test and chi-square test, with p<0.05 considered statistically significant.
resultsThe exposed group demonstrated significantly lower CAT activity (18.25 ± 4.07 vs. 22.46 ± 4.34 U/mg Hb, p=0.001), higher SOD activity (210.52 ± 32.38 vs. 180.21 ± 29.71 U/mg Hb, p=0.004), and elevated MDA levels (4.84 ± 1.21 vs. 3.12 ± 0.92 µmol/L, p=0.002). Moreover, NO (35.74 ± 6.81 vs. 26.05 ± 5.67 µmol/L, p=0.003) and 3-NTx (18.41 ± 3.59 vs. 12.89 ± 3.14 ng/mL, p=0.001) levels were significantly higher in the exposed group compared to controls.
conclusionOccupational exposure to ionizing radiation is associated with increased oxidative and nitrosative stress, reflected by altered biomarker profiles in radiodiagnostic laboratory personnel. These findings highlight the importance of strict radiation protection measures and suggest a potential role for biomarker monitoring and antioxidant interventions to safeguard worker health.
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