Evidence map›Paper›PMID 41869077›Full record

ArticleInternational journal of pharmaceutics: X2026

Zein-based polysaccharide-tannic acid films as multifunctional barriers to prevent post-surgical adhesions.

Amedeo Ungolo, Marco Ruggeri, Cinzia Boselli, Antonia Icaro Cornaglia, Barbara Vigani, Eleonora Bianchi, Silvia Rossi, Giuseppina Sandri

Abstract read
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In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amedeo UngoloDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Marco RuggeriDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Cinzia BoselliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Antonia Icaro CornagliaDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, via Forlanini 2, 27100 Pavia, Italy.
Barbara ViganiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Eleonora BianchiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Silvia RossiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Giuseppina SandriDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formation of postoperative adhesions remains a significant clinical burden, frequently leading to chronic pain, bowel obstruction, and infertility. Current physical barriers have shown limited success, highlighting the need for multifunctional antiadhesive structure that combine mechanical stability with finely tuned surface properties able to act as slipping layer between adjacent organs. At this purpose polymeric zein (Z) based films doped with Chondroitin sulphated (CS) or Maltodextrin (MDx) and loaded with Tannic acid (TA) were developed and characterized by a multidisciplinary approach. The films proved to reduce muco- and bioadhesion, showed higher hydrophobicity and increased roughness that impaired conformal contact and limited adhesive interactions. Moreover, biological evaluation was performed towards Caco-2 epithelial cells, representing the luminal interface of the abdominal cavity, and NHDF fibroblasts, representing the stromal/serosal side. Proliferation assays and cell morphology confirmed the higher biocompatibility of CS- and MDX-doped films compared with the undoped ones (

Indexed as

Muco- and bio-adhesionPolymeric filmsProtein adsorptionProtein-polysaccharides

Identifiers

PMID41869077
PMCPMC13000534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.