ArticleAdvanced biomedical research2026
The Potential Anti Stress-like Properties of Escitalopram on Improvement of Spatial Memory in Rats Subjected to Predictable and Unpredictable Chronic Mild Stress.
Article in Advanced biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic stress and chronic escitalopram usage affect memory. This research examined the potential anti-stress-like properties of escitalopram in improving spatial memory in rats subjected to predictable and unpredictable chronic mild stress (PCMS and UCMS). Materials and Methods: A total of forty-nine male rats were assigned to various groups: control (Co), sham (Sh), predictable stress (P.St; 2 h daily/21 days), unpredictable stress (UP.St; 2 h daily/21 days), escitalopram (Esc; 10 mg/kg/day for 21 days), and stress groups with escitalopram (P.St-Esc and UP.St-Esc). The Barnes maze test evaluated spatial learning and memory across all groups. Subsequently, the hippocampal weight was measured. Results: Both the P.St and UP.St groups showed significant ( Conclusion: Both PCMS and UCMS adversely affected spatial learning and memory. Additionally, escitalopram improved spatial learning and memory only in rats subjected to PCMS conditions. Therefore, it seems that escitalopram improves learning and memory by different pathways in the PCMS and UCMS conditions. Consequently, it seems that different dosages of escitalopram are required to treat memory deficits due to various types of stress. Left hippocampal atrophy also confirmed the potential role of UCMS conditions in memory impairments.
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