ArticleImaging neuroscience (Cambridge, Mass.)
Towards molecular selectivity in pharmacoimaging: Comment on van den Bosch and Cools.
Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Spatial Collinearity Constrains Multivariate Molecular-Enriched Network Estimation.Human brain mapping · 2026Article
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Abstract
Molecular-enriched fMRI promises to bridge the gap between neurotransmitter systems and macro-scale network dynamics, yet empirical support has remained elusive. Commenting on van den Bosch and Cools (2025), we evaluate the first attempt to validate Receptor-Enriched Analysis of functional Connectivity by Targets (REACT) against individual-level PET data. They found that the effects of methylphenidate on dopamine-enriched networks, but not noradrenaline-enriched networks, tracked individual differences in striatal dopamine synthesis capacity and reward prediction error signaling. While establishing the validity of molecular-enriched networks for this specific use case, the study also exposes critical methodological boundary conditions. We discuss the constraints imposed by spatial collinearity between molecular targets, the influence of state-dependent effects in task-based paradigms, and the necessity of pharmacological blocking studies for establishing causal selectivity. Finally, we look to the future of molecular-informed functional imaging.
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