ArticleAmerican journal of translational research2026
Effects of semiconductor laser combined with compound chlorhexidine- and dexamethasone membrane therapy on periodontal health and gingival crevicular fluid inflammation in patients with chronic periodontal disease.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo explore the effects of a semiconductor laser combined with compound chlorhexidine and dexamethasone membrane in the treatment of chronic periodontal disease, and its effects on periodontal health and gingival crevicular fluid inflammatory factors.
methodsThe clinical data of 100 patients with chronic periodontal disease were retrospectively analyzed. According to different treatment methods, they were divided into a conventional treatment group (n=46, receiving conventional periodontal basic treatment) and a combined treatment group (n=54, receiving conventional treatment plus semiconductor laser and compound chlorhexidine-dexamethasone membrane). Periodontal health-related indicators, gingival crevicular fluid inflammatory factor levels, and Oral Health Impact Profile-14 (OHIP-14) scores were compared before and after treatment. The clinical efficacy and occurrence of adverse reactions were evaluated.
resultsAfter treatment, the plaque index, probing depth, sulcus bleeding index, attachment loss, interleukin-6, high-sensitivity C-reactive protein and tumor necrosis factor-αlevels were lower than before treatment, and the OHIP-14 scores were improved (all P<0.05), with significantly more improvement in the combined treatment group (all P<0.05). The conventional treatment group had higher overall effective rate, shorter symptom improvement time (gingival swelling and pain, bad breath, loose teeth) and lower incidence of adverse reactions (all P<0.05).
conclusionSemiconductor laser combined with compound chlorhexidine and dexamethasone membrane has definite clinical effects for chronic periodontal disease. It can effectively improve periodontal health, reduce the levels of inflammation in gingival crevicular fluid, improve patients' quality of life, and is highly safe.
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